TISAGENLECLEUCEL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 08:49:25 GMT 2023` Edited by `admin` on `Sat Dec 16 08:49:25 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	T-CELLS
Record UNII	Q6C9WHR03O
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TISAGENLECLEUCEL

Official Name

English

CTL019

Code

English

CAR.CD19-REDIRECTED T CELLS

Common Name

English

GENE MODIFICATION OF T CELLS IS MEDIATED BY STABLE INSERTION VIA TRANSDUCTION WITH A SELF-INACTIVATING, REPLICATION-DEFICIENT LENTIVIRAL (LV) VECTOR CONTAINING THE CTL019 TRANSGENE UNDER THE CONTROL OF THE EF-1 ALPHA PROMOTER. THE DRUG PRODUCT IS A MIXTU

Common Name

English

TISAGENLECLEUCEL [USAN]

Common Name

English

KYMRIAH

Brand Name

English

Tisagenlecleucel [WHO-DD]

Common Name

English

tisagenlecleucel [INN]

Common Name

English

TISAGENLECLEUCEL-T

Common Name

English

CTL-019

Code

English

CART-19

Code

English

CART19

Code

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/14/1266

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

FDA ORPHAN DRUG

463114

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

FDA ORPHAN DRUG

415113

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

NCI_THESAURUS

C137999

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

NCI_THESAURUS

C28681

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

NCI_THESAURUS

C129826

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

FDA ORPHAN DRUG

422013

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

FDA ORPHAN DRUG

765120

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

Code System Code Type Description

FDA UNII

Q6C9WHR03O

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

EVMPD

SUB177825

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

USAN

BC-84

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

NCI_THESAURUS

C102758

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

CAS

1823078-37-0

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

ChEMBL

CHEMBL3301574

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

DAILYMED

Q6C9WHR03O

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

RXCUI

1986438

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

INN

10557

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

WIKIPEDIA

Tisagenlecleucel

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

DRUG BANK

DB13881

Created by admin on Sat Dec 16 08:49:25 GMT 2023 , Edited by admin on Sat Dec 16 08:49:25 GMT 2023

PRIMARY

Related Record Type Details


					5NR8DJ6FGO

4-1BB COSTIMULATORY DOMAIN

CHIMERIC PROTEIN ELEMENT->PARENT

Amount:


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:


					8VYB4KU0A4

CD3 ZETA CHAIN SIGNALLING DOMAIN

CHIMERIC PROTEIN ELEMENT->PARENT

Amount:

Related Record Type Details


					Q6C9WHR03O

TISAGENLECLEUCEL

ACTIVE MOIETY

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL		HUMAN INTERLEUKIN 2, RECOMBINANT NON-GLYCOSYLATED	72WT6YGC0U
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS	RECEPTOR EXPRESSION	RETROVIRAL TRANSFECTION		UNSPECIFIED SUBSTANCE	d5204918
T-CELL SELECTION AND ACTIVATION	ACTIVATOR	IMMUNOLOGICAL		UNSPECIFIED SUBSTANCE	4e4ac683

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					TISAGENLECLEUCEL CAR-T RECEPTOR	E1A4B5F3ZQ

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				TISSUE MEASURED PHARMACOKINETIC

CD4/CD8 RATIO	BIOLOGICAL