CLOREXOLONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H17ClN2O3S
Molecular Weight	328.814
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CLOREXOLONE

Structure Search

SMILES

NS(=O)(=O)C1=CC2=C(CN(C3CCCCC3)C2=O)C=C1Cl

InChI

InChIKey=VPMWFZKOWULPGT-UHFFFAOYSA-N

InChI=1S/C14H17ClN2O3S/c15-12-6-9-8-17(10-4-2-1-3-5-10)14(18)11(9)7-13(12)21(16,19)20/h6-7,10H,1-5,8H2,(H2,16,19,20)

HIDE SMILES / InChI

Molecular Formula	C14H17ClN2O3S
Molecular Weight	328.814
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.nature.com/nature/journal/v202/n4929/abs/202300a0.html
Curator's Comment: description was created based on several sources, including, http://dtb.bmj.com/content/3/6/24.abstract

Clorexolone is a diuretic developed by May & Baker for the treatment of hypertension. The drug was marketed under the name Nefrolan, however its current status is unknown and supposed to be discontinued, at least in Europe.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: http://pmj.bmj.com/content/41/479/local/advertising.pdf	Palliative		Approved 8429	NEFROLAN Approved Use Unknown

PubMed

PubMed

Title	Date	PubMed
Lithium and the antidiuretic hormone.	1976 Apr	788747

Patents

Patents

Sample Use Guides

In Vivo Use Guide

One 10 mg Tablet once or twice daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:17:35 GMT 2023` Edited by `admin` on `Fri Dec 15 16:17:35 GMT 2023`
Record UNII	Q2PLT3FS05
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CLOREXOLONE

Official Name

English

CLOREXOLONE [USAN]

Common Name

English

Clorexolone [WHO-DD]

Common Name

English

clorexolone [INN]

Common Name

English

6-Chloro-2-cyclohexyl-3-oxo-5-isoindolinesulfonamide

Systematic Name

English

CLOREXOLONE [MART.]

Common Name

English

1H-ISOINDOLE-5-SULFONAMIDE, 6-CHLORO-2-CYCLOHEXYL-2,3-DIHYDRO-3-OXO-

Systematic Name

English

CLOREXOLONE [MI]

Common Name

English

CLOREXOLONE [JAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC03BA82

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

NCI_THESAURUS

C448

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

WHO-VATC

QC03BA12

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

WHO-ATC

C03BA12

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

WHO-ATC

C03BA82

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

Code System Code Type Description

INN

1795

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

PRIMARY

EVMPD

SUB06754MIG

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

PRIMARY

MESH

C017137

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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ChEMBL

CHEMBL2106167

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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DRUG BANK

DB13617

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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MERCK INDEX

m1084

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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Merck Index

WIKIPEDIA

Clorexolone

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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NCI_THESAURUS

C81075

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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CAS

2127-01-7

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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SMS_ID

100000084024

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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EPA CompTox

DTXSID4057683

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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ECHA (EC/EINECS)

218-342-6

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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PUBCHEM

16473

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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DRUG CENTRAL

712

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

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FDA UNII

Q2PLT3FS05

Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023

PRIMARY

Related Record Type Details


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