CLOREXOLONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H17ClN2O3S
Molecular Weight	328.814
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=C(Cl)C=C2CN(C3CCCCC3)C(=O)C2=C1

InChI

InChIKey=VPMWFZKOWULPGT-UHFFFAOYSA-N

InChI=1S/C14H17ClN2O3S/c15-12-6-9-8-17(10-4-2-1-3-5-10)14(18)11(9)7-13(12)21(16,19)20/h6-7,10H,1-5,8H2,(H2,16,19,20)

HIDE SMILES / InChI

Molecular Formula	C14H17ClN2O3S
Molecular Weight	328.814
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.nature.com/nature/journal/v202/n4929/abs/202300a0.html
Curator's Comment: description was created based on several sources, including, http://dtb.bmj.com/content/3/6/24.abstract

Clorexolone is a diuretic developed by May & Baker for the treatment of hypertension. The drug was marketed under the name Nefrolan, however its current status is unknown and supposed to be discontinued, at least in Europe.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575 Sources: http://pmj.bmj.com/content/41/479/local/advertising.pdf	Palliative		Approved 8583	NEFROLAN Approved Use Unknown

Doses

Dose	Population	Adverse events
25 mg 1 times / day multiple, oral Studied dose Dose: 25 mg, 1 times / day Route: oral Route: multiple Dose: 25 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5934250/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/5934250/	Sources: https://pubmed.ncbi.nlm.nih.gov/5934250/

PubMed

Title	Date	PubMed
Lithium and the antidiuretic hormone.	1976-04	788747

Patents

Sample Use Guides

In Vivo Use Guide

One 10 mg Tablet once or twice daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:24:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:24:14 GMT 2025`
Record UNII	Q2PLT3FS05
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOREXOLONE

Official Name

English

CLOREXOLONE [JAN]

Preferred Name

English

CLOREXOLONE [USAN]

Common Name

English

Clorexolone [WHO-DD]

Common Name

English

clorexolone [INN]

Common Name

English

6-Chloro-2-cyclohexyl-3-oxo-5-isoindolinesulfonamide

Systematic Name

English

CLOREXOLONE [MART.]

Common Name

English

1H-ISOINDOLE-5-SULFONAMIDE, 6-CHLORO-2-CYCLOHEXYL-2,3-DIHYDRO-3-OXO-

Systematic Name

English

CLOREXOLONE [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC03BA82