XR-11576

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H24N4O2
Molecular Weight	388.4623
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=C2C=CC3=C(N=C4C(C=CC=C4C(=O)N[C@H](C)CN(C)C)=N3)C2=CC=C1

InChI

InChIKey=ACAXGYADTLFREX-CQSZACIVSA-N

InChI=1S/C23H24N4O2/c1-14(13-27(2)3)24-23(28)17-8-5-9-18-22(17)26-21-16-7-6-10-20(29-4)15(16)11-12-19(21)25-18/h5-12,14H,13H2,1-4H3,(H,24,28)/t14-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H24N4O2
Molecular Weight	388.4623
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical
Record UNII	Q2L4XU3YX6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

XR-11576

Code

English

XR11576

Preferred Name

English

BENZO(A)PHENAZINE-11-CARBOXAMIDE, N-((1R)-2-(DIMETHYLAMINO)-1-METHYLETHYL)-4-METHOXY-

Systematic Name

English

N-((1R)-2-(DIMETHYLAMINO)-1-METHYL-ETHYL)-4-METHOXY-BENZO(A)PHENAZINE-11-CARBOXAMIDE

Systematic Name

English

MLN-576

Code

English

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Code System

Code

Type

Description

PUBCHEM

9886593

PRIMARY

CAS

346689-77-8

PRIMARY

FDA UNII

Q2L4XU3YX6

PRIMARY

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Related Record

Type

Details


					Q2L4XU3YX6

XR-11576

ACTIVE MOIETY

Comments:

Mechanism of Action: DNA topoisomerase I inhibitors, Type II DNA topoisomerase inhibitors; Highest Development Phase: Discontinued for Cancer


					Q2L4XU3YX6

XR-11576

ACTIVE MOIETY

Comments:

XR11576, a novel phenazine, was developed as an inhibitor of both topoisomerase I and II. XR11576 demonstrated potent cytotoxic activity against a variety of human and murine tumor cell lines (IC50=6-47 nM). Its activity profile was comparable to or better than that of many widely used anticancer drugs.

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