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Details

Stereochemistry RACEMIC
Molecular Formula C18H29NO3
Molecular Weight 307.4278
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMPROTROPINE

SMILES

CCN(CC)CC(C)(C)COC(=O)C(CO)C1=CC=CC=C1

InChI

InChIKey=ORXLOAFNULMXBG-UHFFFAOYSA-N
InChI=1S/C18H29NO3/c1-5-19(6-2)13-18(3,4)14-22-17(21)16(12-20)15-10-8-7-9-11-15/h7-11,16,20H,5-6,12-14H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C18H29NO3
Molecular Weight 307.4278
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

AMPROTROPINE (Syntropan) is the phosphate salt of 3 diethylamine, 2.2 dimethylpropanol tropic acid ester. Syntropan is antispasmodic. Its main effect is parasympathetic, and its internal uses are chiefly the same as those of atropine. Syntropan produces relaxation of the tone of the stomach and inhibition of peristaltic activity. The effect of syntropan on gastric secretion excited by a meat extract meal and histamine is weak as compared with atropine. Its advantages as a mydriatic were also described: the rapid effect; the short duration; no general dangers nor discomforts; no local dangers, as damaging the corneal epithelium, or increasing the intraocular pressure; no delay in returning to work for the patient.

Approval Year

PubMed

PubMed

TitleDatePubMed
Syntropan as a mydriatic.
1946 Jun
The effect of syntropan on the motor activities of the human gastrointestinal tract and on gastric acidity.
1949 Jan
Atropine substitutes and the writhing syndrome in mice.
1977 Sep
Patents

Sample Use Guides

Intravenous administration of Syntropan, in doses of 10–25 mg, decreased tonus and abolished waves for short periods of time in the stomach, duodenum, jejunum, ileum and colon, and also retarded transport of the balloon through the stomach and intestine. Undesirable side effects were encountered in all patients given the drug intravenously in doses of 10–25 mg.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:15:28 GMT 2023
Edited
by admin
on Fri Dec 15 16:15:28 GMT 2023
Record UNII
Q1S268DPRS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMPROTROPINE
Common Name English
1-PROPANOL, 3-(DIETHYLAMINO)-2,2-DIMETHYL-, TROPATE (ESTER)
Common Name English
(±)-3-DIETHYLAMINO-2,2-DIMETHYLPROPYL TROPATE
Systematic Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, 3-(DIETHYLAMINO)-2,2-DIMETHYLPROPYL ESTER
Common Name English
TROPIC ACID, 3-(DIETHYLAMINO)-2,2-DIMETHYLPROPYL ESTER
Common Name English
3-DIETHYLAMINO-2,2-DIMETHYLPROPYL TROPATE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
Code System Code Type Description
MESH
C053014
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
CAS
148-32-3
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
PUBCHEM
8645
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID90933277
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
NCI_THESAURUS
C79938
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
FDA UNII
Q1S268DPRS
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
DRUG CENTRAL
3675
Created by admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
PRIMARY
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