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Details

Stereochemistry ACHIRAL
Molecular Formula C10H14N2O3
Molecular Weight 210.2298
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APROBARBITAL

SMILES

CC(C)C1(CC=C)C(=O)NC(=O)NC1=O

InChI

InChIKey=UORJNBVJVRLXMQ-UHFFFAOYSA-N
InChI=1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)

HIDE SMILES / InChI

Molecular Formula C10H14N2O3
Molecular Weight 210.2298
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Aprobarbital is a barbiturate derivative. Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Originator

Curator's Comment: On Saturday, March 12, 1927, a U.S. federal trademark registration was filed for ALURATE (trade name for Aprobarbital) by Hoffmann-La Roche Inc.. According to Wikipedia Aprobarbital was invented in the 1920s by Ernst Preiswerk (No additional reference available). # Hoffmann-La Roche Inc.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ALURATE

Approved Use

Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Launch Date

-1.35103683E12
Primary
ALURATE

Approved Use

Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Launch Date

-1.35112321E12
PubMed

PubMed

TitleDatePubMed
Permanent impairment of renal function after methicillin nephropathy.
1971 Nov 13
Determination of zidovudine/lamivudine/nevirapine in human plasma using ion-pair HPLC.
2002 Jun 1
Patents

Patents

Sample Use Guides

Usual adult dose Hypnotic: Oral, 40 to 160 mg at bedtime. Sedative: Daytime—Oral, 40 mg three times a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:59:32 UTC 2023
Edited
by admin
on Fri Dec 15 14:59:32 UTC 2023
Record UNII
Q0YKG9L6RF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
APROBARBITAL
HSDB   INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
APROBARBITAL [MI]
Common Name English
5-ALLYL-5-ISOPROPYLBARBITURIC ACID
Systematic Name English
NSC-120769
Code English
Aprobarbital [WHO-DD]
Common Name English
APROBARBITAL [MART.]
Common Name English
APROBARBITAL [HSDB]
Common Name English
ALURATE
Brand Name English
APROBARBITAL [VANDF]
Common Name English
aprobarbital [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67084
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
WHO-ATC N05CA05
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
DEA NO. 2100
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
WHO-VATC QN05CA05
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
Code System Code Type Description
INN
1161
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
PUBCHEM
6464
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
FDA UNII
Q0YKG9L6RF
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
NSC
120769
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
EPA CompTox
DTXSID8022616
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
ChEMBL
CHEMBL7863
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-997-4
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
CHEBI
2791
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
MESH
C006470
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
HSDB
3290
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
WIKIPEDIA
APROBARBITAL
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
DRUG CENTRAL
232
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
CAS
77-02-1
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
SMS_ID
100000087182
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
EVMPD
SUB05543MIG
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
MERCK INDEX
m2015
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C76525
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
RXCUI
17381
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB01352
Created by admin on Fri Dec 15 14:59:32 UTC 2023 , Edited by admin on Fri Dec 15 14:59:32 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY