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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11ClF3N3.ClH
Molecular Weight 302.124
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Org-12962 hydrochloride

SMILES

Cl.FC(F)(F)C1=CC=C(N=C1Cl)N2CCNCC2

InChI

InChIKey=FVDILXYXZAAJOS-UHFFFAOYSA-N
InChI=1S/C10H11ClF3N3.ClH/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17;/h1-2,15H,3-6H2;1H

HIDE SMILES / InChI
Molecular Formula C10H11ClF3N3
Molecular Weight 265.663
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Org-12962 was developed by Organon as a potent and selective Serotonin 5-HT(2C) receptor agonist. It was in clinical trial phase II for depression treatment, but the investigation was discontinued. In addition, was shown, Org-12962 displayed antiaversive effects in a rat model of panic-like anxiety.

Originator

Organon
34
Curator's Comment: Organon (acquired by Schering-Plough, now a division of Merck Sharp and Dohme)

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2752
 7.01 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase II
1147
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Patents

US2014155369
2
US2015238506
3
US7396854
2
US7595314
2
US8158617
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Apr 02 16:14:21 GMT 2025
Edited
by admin
on Wed Apr 02 16:14:21 GMT 2025
Record UNII
PZ5RGN8MR8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Org-12962 hydrochloride
Common Name English
Ro-44-6956
Preferred Name English
1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine hydrochloride (1:1)
Systematic Name English
Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, hydrochloride (1:1)
Systematic Name English
Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, monohydrochloride
Systematic Name English
Code System Code Type Description
FDA UNII
PZ5RGN8MR8
Created by admin on Wed Apr 02 16:14:21 GMT 2025 , Edited by admin on Wed Apr 02 16:14:21 GMT 2025
PRIMARY
PUBCHEM
9796407
Created by admin on Wed Apr 02 16:14:21 GMT 2025 , Edited by admin on Wed Apr 02 16:14:21 GMT 2025
PRIMARY
EPA CompTox
DTXSID60430869
Created by admin on Wed Apr 02 16:14:21 GMT 2025 , Edited by admin on Wed Apr 02 16:14:21 GMT 2025
PRIMARY
CAS
210821-63-9
Created by admin on Wed Apr 02 16:14:21 GMT 2025 , Edited by admin on Wed Apr 02 16:14:21 GMT 2025
PRIMARY
Related Record Type Details
Structure of ORG-12962
PARENT -> SALT/SOLVATE
NIH
NCATS
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