ORG-12962

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H11ClF3N3
Molecular Weight	265.663
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C1=CC=C(N=C1Cl)N2CCNCC2

InChI

InChIKey=QZYYPQAYSFBKPW-UHFFFAOYSA-N

InChI=1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2

HIDE SMILES / InChI

Molecular Formula	C10H11ClF3N3
Molecular Weight	265.663
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9716307 | https://www.ncbi.nlm.nih.gov/pubmed/10498829

Org-12962 was developed by Organon as a potent and selective Serotonin 5-HT(2C) receptor agonist. It was in clinical trial phase II for depression treatment, but the investigation was discontinued. In addition, was shown, Org-12962 displayed antiaversive effects in a rat model of panic-like anxiety.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2c (5-HT2c) receptor 124 Target ID: CHEMBL225 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10498829	Agonist 2678		7.01 null [pEC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: Leonard, B.E. (2012) Antidepressants, page 131, retrieved from: https://books.google.ru/books?id=NYIECAAAQBAJ	Primary		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.	1998 Aug	9716307
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.	2004 Aug	15322733
Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity.	2005 Mar	15777190

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:59:06 GMT 2023` Edited by `admin` on `Sat Dec 16 16:59:06 GMT 2023`
Record UNII	TUK9RFW5YL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORG-12962

Code

English

Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-

Systematic Name

English

Org12692

Code

English

1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID70430870