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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11ClF3N3
Molecular Weight 265.663
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ORG-12962

SMILES

FC(F)(F)C1=CC=C(N=C1Cl)N2CCNCC2

InChI

InChIKey=QZYYPQAYSFBKPW-UHFFFAOYSA-N
InChI=1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2

HIDE SMILES / InChI

Molecular Formula C10H11ClF3N3
Molecular Weight 265.663
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Org-12962 was developed by Organon as a potent and selective Serotonin 5-HT(2C) receptor agonist. It was in clinical trial phase II for depression treatment, but the investigation was discontinued. In addition, was shown, Org-12962 displayed antiaversive effects in a rat model of panic-like anxiety.

Originator

Curator's Comment: Organon (acquired by Schering-Plough, now a division of Merck Sharp and Dohme)

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
7.01 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.
1998 Aug
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
2004 Aug
Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity.
2005 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Apr 02 08:40:26 GMT 2025
Edited
by admin
on Wed Apr 02 08:40:26 GMT 2025
Record UNII
TUK9RFW5YL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Org12692
Preferred Name English
ORG-12962
Code English
Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-
Systematic Name English
1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID70430870
Created by admin on Wed Apr 02 08:40:26 GMT 2025 , Edited by admin on Wed Apr 02 08:40:26 GMT 2025
PRIMARY
WIKIPEDIA
ORG-12962
Created by admin on Wed Apr 02 08:40:26 GMT 2025 , Edited by admin on Wed Apr 02 08:40:26 GMT 2025
PRIMARY
CAS
132834-56-1
Created by admin on Wed Apr 02 08:40:26 GMT 2025 , Edited by admin on Wed Apr 02 08:40:26 GMT 2025
PRIMARY
FDA UNII
TUK9RFW5YL
Created by admin on Wed Apr 02 08:40:26 GMT 2025 , Edited by admin on Wed Apr 02 08:40:26 GMT 2025
PRIMARY
PUBCHEM
9796408
Created by admin on Wed Apr 02 08:40:26 GMT 2025 , Edited by admin on Wed Apr 02 08:40:26 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SALT/SOLVATE -> PARENT
TARGET -> AGONIST