BENZOPHENONE-2

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H10O5
Molecular Weight	246.2155
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC(O)=C(C=C1)C(=O)C2=C(O)C=C(O)C=C2

InChI

InChIKey=WXNRYSGJLQFHBR-UHFFFAOYSA-N

InChI=1S/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17H

HIDE SMILES / InChI

Molecular Formula	C13H10O5
Molecular Weight	246.2155
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.	2001 Feb	11266322
Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone.	2004 Dec 1	15458795
[Estrogenic activity of ultraviolet absorbers and the related compounds].	2005 Aug	16079615
Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.	2005 Feb 15	15694459
Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats.	2005 Sep 15	15951094
In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes.	2006	16997798
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.	2006 Oct	16586070
Effects of the UV filter benzophenone-2 on reproduction in fish.	2007 Dec 15	17889917
The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.	2007 Jun	17379648
In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism.	2007 Oct	17707034
Pharmacokinetics and metabolism of benzophenone 2 in the rat.	2008 Mar 12	18242814
Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.	2009 Jan 1	18992764
Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.	2010 Feb 15	19913605
True photoallergy to sunscreens is rare despite popular belief.	2010 Jul-Aug	20646669
Effect of 2,2',4,4'-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells.	2011 Oct 9	21726595
Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.	2011 Sep 1	21800831
Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line.	2011 Sep 15	21809831
Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.	2012 Feb	22045033
Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.	2014 Oct 1	25106122

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:51:17 GMT 2023` Edited by `admin` on `Fri Dec 15 15:51:17 GMT 2023`
Record UNII	PRR8K3H9VN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZOPHENONE-2

Official Name

English

BENZOPHENONE 2

Common Name

English

2,2',4,4'-TETRAHYDROXYBENZOPHENONE

Systematic Name

English

BENZOPHENONE, 2,2',4,4'-TETRAHYDROXY-

Systematic Name

English

BENZOPHENONE-2 [INCI]

Common Name

English

NSC-38556

Code

English

METHANONE, BIS(2,4-DIHYDROXYPHENYL)-

Systematic Name

English

Code System Code Type Description

RXCUI

1315125