RUBIDIUM CATION

Details

Stereochemistry	ACHIRAL
Molecular Formula	Rb
Molecular Weight	85.4678
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

[Rb+]

InChI

InChIKey=NCCSSGKUIKYAJD-UHFFFAOYSA-N

InChI=1S/Rb/q+1

HIDE SMILES / InChI

Molecular Formula	Rb
Molecular Weight	85.4678
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8926857
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267

Rubidium chloride is an inorganic compound with the formula RbCl. It appears to be nontoxic and therapeutically effective in several types of depressive disorders. This drug develops his action on dopaminergic stimulation reducing the depressive pattern. Also radioactive rubidium-82 chloride is used as diagnostic agent in positron emission tomography (PET).

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: Placidi, G.F. et al. (2012) Recurrent Mood Disorders, retrieved from: https://books.google.ru/books?id=pIvcBQAAQBAJ	Primary		Approved 8429	RUBINORM Approved Use Depression

PubMed

Title	Date	PubMed
Brain norepinephrine: enhanced turnover after rubidium treatment.	1970 Apr 24	5436089
Rubidium chloride ingestion by volunteer subjects: initial experience.	1971	5561654
Effects of rubidium chloride on the course of manic-depressive illness.	1978 May	349155
Nerve fibre refractory period in patients treated with rubidium and lithium.	1978 Sep	690649
Exploration of the clinical profile of rubidium chloride in depression: a systematic open trial.	1988 Jun	3379141
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Inhibition of HIV-1 infection by zinc group metal compounds.	1999 Sep	10517314
Gating properties of inward-rectifier potassium channels: effects of permeant ions.	2001 Nov 1	11687881
Protein kinase C-epsilon modulates mitochondrial function and active Na+ transport after oxidant injury in renal cells.	2004 Feb	14570699

Patents

Sample Use Guides

In Vivo Use Guide

540 mg/day

Route of Administration: Oral

In Vitro Use Guide

Rubidium chloride accelerated cAMP synthesis in rat brain cortex membranes. The effect was dose-dependent and yielded above 2-fold activation of adenylate cyclase. It has been shown that Rb+ influenced directly the catalytic subunit of the enzyme and did not substitute Mg2+ in formation of the metal-ATP complex in this reaction. The stimulatory effect of Rb+ was additive to the activation of adenylate cyclase by the half-maximal (0.3 microM) as well as by the saturating (10 microM) forskolin concentrations, pointing to the fact that these effectors activate different isoforms of the enzyme in rat brain cortex.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:32:01 UTC 2023` Edited by `admin` on `Sat Dec 16 18:32:01 UTC 2023`
Record UNII	PR87B22TGJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RUBIDIUM CATION

Common Name

English

RUBIDIUM ION

Common Name

English

RUBIDIUM ION(1+)

Common Name

English

RUBIDIUM(1+)

Systematic Name

English

RUBIDIUM, ION (RB1+)

Systematic Name

English

Code System Code Type Description

PUBCHEM

105153