TAT-NR2B9C is a synthetic peptide fusion of the nine C-terminal residues of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor and the cell membrane protein transduction domain of the HIV-1 tat protein. It is a postsynaptic density protein-95 (PSD95) inhibitor with neuroprotective properties. It is under development for the treatment of acute stroke and acute cerebral ischemia.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/31213815
Curator's Comment: Low brain penetrability.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. | 2007 Sep 12 |
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Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat. | 2017 Jan |
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Discovery and development of NA-1 for the treatment of acute ischemic stroke. | 2018 May |
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:14:44 GMT 2023
by
admin
on
Sat Dec 16 14:14:44 GMT 2023
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Protein Type | PEPTIDE |
Protein Sub Type | |
Sequence Type | COMPLETE |
Record UNII |
PLO8CTF5WR
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Record Status |
Validated (UNII)
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Record Version |
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C174845
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GH-180
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155558146
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2273883-74-0
Created by
admin on Sat Dec 16 14:14:44 GMT 2023 , Edited by admin on Sat Dec 16 14:14:44 GMT 2023
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NON-SPECIFIC STOICHIOMETRY | |||
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PLO8CTF5WR
Created by
admin on Sat Dec 16 14:14:44 GMT 2023 , Edited by admin on Sat Dec 16 14:14:44 GMT 2023
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
neurological agent
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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Molecular Formula | CHEMICAL |
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