PECAZINE

CN1CCCC(CN2C3=C(SC4=C2C=CC=C4)C=CC=C3)C1

InChIKey=CBHCDHNUZWWAPP-UHFFFAOYSA-N

InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

PECAZINE is a phenothiazine derivative that was used as an antipsychotic. It is also an allosteric inhibitor of MALT1 paracaspase activity.

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Dose	Population	Adverse events
75 mg 3 times / day multiple, oral Recommended	unhealthy, 20-59 n = 33	Disc. AE: Agranulocytosis...
50 mg 3 times / day multiple, oral Recommended	unhealthy, 35 n = 1	Disc. AE: Agranulocytosis...
300 mg multiple, oral Recommended	unhealthy, 37.1±1.5 n = 50	Disc. AE: Cycloplegia...
900 mg multiple, oral Highest studied dose	unhealthy n = 2
25 mg 3 times / day multiple, oral Studied dose	unhealthy n = 2	Disc. AE: Jaundice...

Showing 1 to 5 of 5 entries

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AE	Significance	Dose	Population
Agranulocytosis	3% Disc. AE	75 mg 3 times / day multiple, oral Recommended	unhealthy, 20-59 n = 33
Agranulocytosis	Disc. AE	50 mg 3 times / day multiple, oral Recommended	unhealthy, 35 n = 1
Cycloplegia	4% Disc. AE	300 mg multiple, oral Recommended	unhealthy, 37.1±1.5 n = 50
Jaundice	Disc. AE	25 mg 3 times / day multiple, oral Studied dose	unhealthy n = 2

Showing 1 to 4 of 4 entries

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Vendor/Aggregator	ID	URL
001 Chemical	DY562589	https://www.001chemical.com/chem/60-89-9
Alfa Chemistry	60-89-9	https://www.alfa-chemistry.com/cas_60-89-9.htm
Aurora Fine Chemicals LLC	K02.237.593	http://online.aurorafinechemicals.com/info?ID=K02.237.593
Chem Scene	CS-0081367	http://www.chemscene.com/60-89-9.html
Chemspace	CSSS00102561680	https://chem-space.com/CSSS00102561680

Showing 1 to 5 of 15 entries

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Title	Date	PubMed
Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology.	2010 Mar 3	20209133
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003