SURVIVIN-2B (80-88)

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C39H62N10O15S
Molecular Weight	943.033
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(O)=O

InChI

InChIKey=AGNIXLPCPQAPSB-SXHLWKDOSA-N

InChI=1S/C39H62N10O15S/c1-16(2)11-25(39(63)64)45-37(61)29(19(5)51)49-35(59)26(14-50)46-38(62)30(20(6)52)48-34(58)24(13-28(41)54)44-36(60)27(15-65)47-32(56)18(4)42-33(57)23(43-31(55)17(3)40)12-21-7-9-22(53)10-8-21/h7-10,16-20,23-27,29-30,50-53,65H,11-15,40H2,1-6H3,(H2,41,54)(H,42,57)(H,43,55)(H,44,60)(H,45,61)(H,46,62)(H,47,56)(H,48,58)(H,49,59)(H,63,64)/t17-,18-,19+,20+,23-,24-,25-,26-,27-,29-,30-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C39H62N10O15S
Molecular Weight	943.033
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	1
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:43:10 GMT 2023` Edited by `admin` on `Sat Dec 16 11:43:10 GMT 2023`
Record UNII	PGQ5HC5AMU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SURVIVIN-2B (80-88)

Common Name

English

ALA-TYR-ALA-CYS-ASN-THR-SER-THR-LEU

Systematic Name

English

SURVIVIN-2B (80-88) PEPTIDE

Common Name

English

(2S)-2-(((2S,3R)-2-(((2S)-2-(((2S,3R)-2-(((2S)-4-AMINO-2-(((2R)-2-(((2S)-2-(((2S)-2-(((2S)-2-AMINOPROPANOYL)AMINO)-3-(4-HYDROXYPHENYL)PROPANOYL)AMINO)PROPANOYL)AMINO)-3-SULFANYL-PROPANOYL)AMINO)-4-OXO-BUTANOYL)AMINO)-3-HYDROXY-BUTANOYL)AMINO)-3-HYDROXY-P

Systematic Name

English

SVN-2B

Common Name

English

SURVIVIN-2B

Common Name

English

L-LEUCINE, L-ALANYL-L-TYROSYL-L-ALANYL-L-CYSTEINYL-L-ASPARAGINYL-L-THREONYL-L-SERYL-L-THREONYL-

Systematic Name

English

Code System Code Type Description

PUBCHEM

10284618

Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023

PRIMARY

CAS

465500-22-5

Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023

PRIMARY

FDA UNII

PGQ5HC5AMU

Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023

PRIMARY

WIKIPEDIA

Survivin

Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023

PRIMARY

The single survivin gene can give rise to four different alternatively spliced transcripts: Survivin-2B, which has an insertion of an alternative exon 2.

Related Record Type Details


					PGQ5HC5AMU

SURVIVIN-2B (80-88)

ACTIVE MOIETY

Comments:

Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others, and the mechanisms are unclear. In this report, we discovered that selenite, an antitumor agent, switched protective autophagy to apoptosis in NB4 cells. In this process, the level of survivin-2B was decreased and the interaction between IKK alpha and survivin-2B in the nucleus was attenuated, which further led to the decrease of nuclear IKK alpha. As a result, P73, a known transcript factor of UVRAG, was downregulated. Therefore, the expression of UVRAG, one of the initiators of autophagy, was inhibited. The regulatory status of survivin-2B was also proved in NB4 cells after different chemicals exposure and in other tumor cell lines (Jurkat, HCT116). Finally, experiments in vivo confirmed that the alterations of survivin-2B, IKK alpha, P73 and UVRAG were the same as that in vitro. Taken together, survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus.