U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:35:54 UTC 2023
Edited
by admin
on Sat Dec 16 18:35:54 UTC 2023
Source Materials Class ORGANISM
Source Materials Type ALLOGENIC HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name T cells
Record UNII
PFZ3AP93TA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZERCABTAGENE ZAPRELEUCEL
USAN   INN  
Official Name English
AZERCABTAGENE ZAPRELEUCEL [USAN]
Common Name English
azercabtagene zapreleucel [INN]
Common Name English
Adult allogeneic CD4+ and CD8+ enriched T cells transduced with an anti-CD19 chimeric antigen receptor (CAR) that is site-specific integrated into the cellular genome. Adult allogeneic CD4+ and CD8+ enriched T cells, gene edited through the electroporati
Common Name English
PBCAR-0191
Code English
PBCAR0191
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 738020
Created by admin on Sat Dec 16 18:35:54 UTC 2023 , Edited by admin on Sat Dec 16 18:35:54 UTC 2023
Code System Code Type Description
USAN
KL-105
Created by admin on Sat Dec 16 18:35:54 UTC 2023 , Edited by admin on Sat Dec 16 18:35:54 UTC 2023
PRIMARY
NCI_THESAURUS
C158558
Created by admin on Sat Dec 16 18:35:54 UTC 2023 , Edited by admin on Sat Dec 16 18:35:54 UTC 2023
PRIMARY
FDA UNII
PFZ3AP93TA
Created by admin on Sat Dec 16 18:35:54 UTC 2023 , Edited by admin on Sat Dec 16 18:35:54 UTC 2023
PRIMARY
INN
11438
Created by admin on Sat Dec 16 18:35:54 UTC 2023 , Edited by admin on Sat Dec 16 18:35:54 UTC 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE UNSPECIFIED SUBSTANCE 2399a508
CULTURED ENRICHMENT UNSPECIFIED SUBSTANCE 5c1f06ef
ADENOVIRUS TRANSFECTION TRANSFECTION UNSPECIFIED SUBSTANCE fe9e4201

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN UNSPECIFIED SUBSTANCE
ea310732
(not in database)
TRANSGENE UNSPECIFIED SUBSTANCE
09e71fe3
(not in database)
TRANSGENE AZERCABTAGENE ZAPRELEUCEL AAV6 GENE INSERT SU254A6B4S
VECTOR EXPRESSED PROTEIN AZERCABTAGENE ZAPRELEUCEL CHIMERIC ANTIGEN RECEPTOR QVM7J6UNJ3
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN NOT EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL