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Details

Stereochemistry ACHIRAL
Molecular Formula Ca.2HO
Molecular Weight 74.093
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Calcium hydroxide

SMILES

[OH-].[OH-].[Ca++]

InChI

InChIKey=AXCZMVOFGPJBDE-UHFFFAOYSA-L
InChI=1S/Ca.2H2O/h;2*1H2/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:04:29 GMT 2025
Edited
by admin
on Mon Mar 31 18:04:29 GMT 2025
Record UNII
PF5DZW74VN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Calcium hydroxide
EP   FCC   HSDB   II   INCI   MART.   MI   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
Hydrated lime
ISO  
Preferred Name English
CALCIUM HYDROXIDE [JAN]
Common Name English
CALCIUM HYDROXIDE [MI]
Common Name English
LIME HYDRATE
Common Name English
CALCIUM HYDROXIDE SOLUTION [VANDF]
Common Name English
SLAKED LIME
Common Name English
CALCAREA CAUSTICA [HPUS]
Common Name English
Hydrated lime [ISO]
Common Name English
CALCIUM HYDROXIDE [VANDF]
Common Name English
CALCIUM HYDROXIDE [USP-RS]
Common Name English
CALCIUM HYDROXIDE [HSDB]
Common Name English
CALCAREA CAUSTICA
HPUS  
Common Name English
CALCIUM DIHYDROXIDE
Systematic Name English
LIME WATER [VANDF]
Common Name English
CALCIUM HYDROXIDE [MART.]
Common Name English
SLAKED-LIME
Common Name English
Calcium hydroxide [WHO-DD]
Common Name English
INS NO.526
Code English
CALCIUM HYDROXIDE (CA(OH)2)
Common Name English
CALCIUM HYDROXIDE [FCC]
Common Name English
CALCIUM HYDROXIDE [II]
Common Name English
LIME WATER
VANDF  
Common Name English
CALCIUM HYDROXIDE [EP MONOGRAPH]
Common Name English
E-526
Code English
CALCIUM HYDROXIDE [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-526
Created by admin on Mon Mar 31 18:04:29 GMT 2025 , Edited by admin on Mon Mar 31 18:04:29 GMT 2025
CFR 21 CFR 184.1205
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NCI_THESAURUS C28394
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CODEX ALIMENTARIUS (GSFA) INS-526
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EPA PESTICIDE CODE 75601
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Code System Code Type Description
PUBCHEM
14777
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PRIMARY
FDA UNII
PF5DZW74VN
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PRIMARY
SMS_ID
100000076568
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PRIMARY
EVMPD
SUB13180MIG
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PRIMARY
EVMPD
SUB37067
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PRIMARY
RXCUI
1910
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PRIMARY RxNorm
ChEMBL
CHEMBL2106388
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PRIMARY
NCI_THESAURUS
C77032
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PRIMARY
DAILYMED
PF5DZW74VN
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PRIMARY
MESH
D002126
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PRIMARY
CHEBI
31341
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PRIMARY
ECHA (EC/EINECS)
215-137-3
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PRIMARY
CHEBI
35111
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PRIMARY
CAS
1305-62-0
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PRIMARY
HSDB
919
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PRIMARY
WIKIPEDIA
CALCIUM HYDROXIDE
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PRIMARY
MERCK INDEX
m2945
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PRIMARY Merck Index
EPA CompTox
DTXSID7034410
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PRIMARY