CLOMOXIR

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H17ClO3
Molecular Weight	268.736
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C2(CCCCCC1=CC=C(Cl)C=C1)CO2

InChI

InChIKey=ACZKTJZXXSHIGF-UHFFFAOYSA-N

InChI=1S/C14H17ClO3/c15-12-7-5-11(6-8-12)4-2-1-3-9-14(10-18-14)13(16)17/h5-8H,1-4,9-10H2,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C14H17ClO3
Molecular Weight	268.736
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1994902 | https://www.ncbi.nlm.nih.gov/pubmed/3421940 | https://www.ncbi.nlm.nih.gov/pubmed/6213437

Clomoxir (POCA, B 807-27) is a potent inhibitor of mitochondrial fatty acid oxidation at the stage of carnitine palmitoyltransferase I (CPT-I). It acts by the tight binding of POCA-CoA to this enzyme. The compound demonstrated hypoketonaemic and hypoglycaemic activities in fasted normal and diabetic rats.

Approval Year

PubMed

Title	Date	PubMed
Baicalein 5,6,7-trimethyl ether activates peroxisomal but not mitochondrial fatty acid beta-oxidation.	2008-06	18470630

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:20:25 GMT 2025` Edited by `admin` on `Mon Mar 31 18:20:25 GMT 2025`
Record UNII	PD884XOZ9F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOMOXIR

Official Name

English

(±)-2-(5-(P-CHLOROPHENYL)PENTYL)GLYCIDIC ACID

Preferred Name

English

clomoxir [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471