TENONITROZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H5N3O3S2
Molecular Weight	255.274
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CN=C(NC(=O)C2=CC=CS2)S1

InChI

InChIKey=ZLOXYEZYWCTXHU-UHFFFAOYSA-N

InChI=1S/C8H5N3O3S2/c12-7(5-2-1-3-15-5)10-8-9-4-6(16-8)11(13)14/h1-4H,(H,9,10,12)

HIDE SMILES / InChI

Molecular Formula	C8H5N3O3S2
Molecular Weight	255.274
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://euromeds-doctor.com/en/product/tenonitrozole/atrican | http://en.pharmacodia.com/web/drug/1_11004.html

Tenonitrozole is an antiprotozoal given in the treatment of trichomoniasis. It is given orally in a dose of 250 mg twice daily with meals, for 4 days.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
pyruvate synthase activity 1 Target ID: GO:0019164 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21078930	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Urogenital trichomoniasis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5699163	Curative		Approved 8429	ATRICAN Approved Use This medicine contains the active ingredient tenonitrozole which belongs to a group of antiprotozoal agents. This medicine is prescribed for the treatment of urogenital trichomoniasis, which is an infection caused by the parasite Trichomonas vaginalis.

PubMed

Title	Date	PubMed
[UROGENITAL SYNDROMES CAUSED BY "TRICHOMONAS VAGINALIS" AND "CANDIDA ALBICANS". RESULTS OF TREATMENT BY 2-(ALPHA-THENOYLAMINO)-5-NITROTHIAZOLE].	1963 Dec 28	14102450
[THE INFLUENCE OF ATRICAN (ALPHA-THENOYL-AMINO-2-NITRO-5-THIAZOLE) ON THE PREGNANCY AND FETAL DEVELOPMENT OF THE RAT, MOUSE AND RABBIT].	1964 May 20	14150938
Development of 5-nitrothiazole derivatives: identification of leads against both replicative and latent Mycobacterium tuberculosis.	2012 Dec 15	23137434

Patents

Sample Use Guides

In Vivo Use Guide

Urogenital trichomoniasis treatment: The usual dose is 1 capsule in the morning and 1 capsule (250 mg) in the evening during meals, for 4 days. Both partners should be treated simultaneously.

Route of Administration: Oral

In Vitro Use Guide

Tenonitrozole inhibited Giardia with IC50 value of 0.19 uM

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:22:28 GMT 2023` Edited by `admin` on `Fri Dec 15 15:22:28 GMT 2023`
Record UNII	PBQ7WLE1WP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TENONITROZOLE

Official Name

English

N-(5-NITRO-2-THIAZOLYL)-2-THIOPHENECARBOXAMIDE

Systematic Name

English

Tenonitrozole [WHO-DD]

Common Name

English

tenonitrozole [INN]

Common Name

English

TENONITROZOLE [MI]

Common Name

English

TENONITROZOLE [MART.]

Common Name

English

ATRICAN

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277