U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H5N3O3S2
Molecular Weight 255.274
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TENONITROZOLE

SMILES

[O-][N+](=O)C1=CN=C(NC(=O)C2=CC=CS2)S1

InChI

InChIKey=ZLOXYEZYWCTXHU-UHFFFAOYSA-N
InChI=1S/C8H5N3O3S2/c12-7(5-2-1-3-15-5)10-8-9-4-6(16-8)11(13)14/h1-4H,(H,9,10,12)

HIDE SMILES / InChI

Molecular Formula C8H5N3O3S2
Molecular Weight 255.274
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tenonitrozole is an antiprotozoal given in the treatment of trichomoniasis. It is given orally in a dose of 250 mg twice daily with meals, for 4 days.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
ATRICAN

PubMed

Sample Use Guides

In Vivo Use Guide
Urogenital trichomoniasis treatment: The usual dose is 1 capsule in the morning and 1 capsule (250 mg) in the evening during meals, for 4 days. Both partners should be treated simultaneously.
Route of Administration: Oral
In Vitro Use Guide
Tenonitrozole inhibited Giardia with IC50 value of 0.19 uM
Substance Class Chemical
Record UNII
PBQ7WLE1WP
Record Status Validated (UNII)
Record Version