TENONITROZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H5N3O3S2
Molecular Weight	255.274
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CN=C(NC(=O)C2=CC=CS2)S1

InChI

InChIKey=ZLOXYEZYWCTXHU-UHFFFAOYSA-N

InChI=1S/C8H5N3O3S2/c12-7(5-2-1-3-15-5)10-8-9-4-6(16-8)11(13)14/h1-4H,(H,9,10,12)

HIDE SMILES / InChI

Molecular Formula	C8H5N3O3S2
Molecular Weight	255.274
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://euromeds-doctor.com/en/product/tenonitrozole/atrican | http://en.pharmacodia.com/web/drug/1_11004.html

Tenonitrozole is an antiprotozoal given in the treatment of trichomoniasis. It is given orally in a dose of 250 mg twice daily with meals, for 4 days.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
pyruvate synthase activity 1 Target ID: GO:0019164 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21078930	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Urogenital trichomoniasis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5699163	Curative		Approved 8583	ATRICAN Approved Use This medicine contains the active ingredient tenonitrozole which belongs to a group of antiprotozoal agents. This medicine is prescribed for the treatment of urogenital trichomoniasis, which is an infection caused by the parasite Trichomonas vaginalis.

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087 inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153 CYP2C19 2057	P-gp 2052

Drug as perpetrator

Target	Modality	Activity
CYP3A4 2633	inducer 1966 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 27.0	no [Activation 12.5893 uM]
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 10.0	yes [IC50 1.8172 uM]
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 25.0	yes [IC50 12.3018 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 17.0	yes [IC50 5.495 uM]
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 19.0	yes [IC50 7.7619 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 20.0	yes [IC50 8.709 uM]

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 2052	substrate 4014 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 169.0	no

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19646#section=BioAssay-Results Page: 145.0

PubMed

Title	Date	PubMed
Development of 5-nitrothiazole derivatives: identification of leads against both replicative and latent Mycobacterium tuberculosis.	2012-12-15	23137434
[THE INFLUENCE OF ATRICAN (ALPHA-THENOYL-AMINO-2-NITRO-5-THIAZOLE) ON THE PREGNANCY AND FETAL DEVELOPMENT OF THE RAT, MOUSE AND RABBIT].	1964-05-20	14150938
[UROGENITAL SYNDROMES CAUSED BY "TRICHOMONAS VAGINALIS" AND "CANDIDA ALBICANS". RESULTS OF TREATMENT BY 2-(ALPHA-THENOYLAMINO)-5-NITROTHIAZOLE].	1963-12-28	14102450

Patents

Sample Use Guides

In Vivo Use Guide

Urogenital trichomoniasis treatment: The usual dose is 1 capsule in the morning and 1 capsule (250 mg) in the evening during meals, for 4 days. Both partners should be treated simultaneously.

Route of Administration: Oral

In Vitro Use Guide

Tenonitrozole inhibited Giardia with IC50 value of 0.19 uM

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:55:34 GMT 2025` Edited by `admin` on `Mon Mar 31 17:55:34 GMT 2025`
Record UNII	PBQ7WLE1WP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TENONITROZOLE

Official Name

English

ATRICAN

Preferred Name

English

N-(5-NITRO-2-THIAZOLYL)-2-THIOPHENECARBOXAMIDE

Systematic Name

English

Tenonitrozole [WHO-DD]

Common Name

English

tenonitrozole [INN]

Common Name

English

TENONITROZOLE [MI]

Common Name

English

TENONITROZOLE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277