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Details

Stereochemistry ACHIRAL
Molecular Formula C9H10N2O2
Molecular Weight 178.1879
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENACEMIDE

SMILES

NC(=O)NC(=O)CC1=CC=CC=C1

InChI

InChIKey=XPFRXWCVYUEORT-UHFFFAOYSA-N
InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)

HIDE SMILES / InChI

Molecular Formula C9H10N2O2
Molecular Weight 178.1879
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Phenacemide, also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class. Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn from the market because of its severe side effects, which includes personality changes, blood, renal and skin disorders.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PHENURONE

Doses

AEs

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

Tox targets

PubMed

Sample Use Guides

In Vivo Use Guide
Phenacemide was administered orally at 500-5000 mg daily dose
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
PAI7J52V09
Record Status Validated (UNII)
Record Version