AVRIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C43H90N2O2
Molecular Weight	667.1869
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO

InChI

InChIKey=WXNRAKRZUCLRBP-UHFFFAOYSA-N

InChI=1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C43H90N2O2
Molecular Weight	667.1869
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/213498 | https://www.ncbi.nlm.nih.gov/pubmed/7882557

CP-20,961 [N,N-dioctadecyl-N',N'-bis (2-hydroxyethyl) propanediamine, or Avridine) is a non-immunogenic adjuvant, which was investigated as an antiviral drug with low acute toxicity in mice. This compound is able to stimulate nasal interferon and was studied in patients with rhinovirus, but the results had shown, that CP-20,961 had yielded both fairly good results and only fair or poor results. CP-20,961 is also used to induce arthritis in rodents.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes.	1995-03	7882557
Antiviral activity of CP-20,961 against herpes simplex viruses in vitro.	1985	2982759
CP-20,961: a structurally novel, synthetic adjuvant.	1979-12	522084
Effect of CP-20,961, an interferon inducer, on upper respiratory tract infections due to rhinovirus type 21 in volunteers.	1978-10	213498
N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl) propanediamine: antiviral activity and interferon stimulation in mice.	1973-04	4364178

Sample Use Guides

In Vivo Use Guide

Induction of arthritis in rats: arthritis was induced in the rats by a subcutaneous injection at the base of the tail of 150 uL avridine solubilized in Freund's incomplete adjuvant at a concentration of 0, 10,25 or 50 mg/ml. Arthritis development was monitored daily by a macroscopic scoring system for the four limbs ranging from 0 to 4.

Route of Administration: Other

In Vitro Use Guide

The antiherpesvirus activity of CP-20,961 [N,N-dioctadecyl-N',N'-bis (2-hydroxyethyl) propanediamine, or Avridine] was investigated in cultured guinea pig embryo (GPE) cells. Plaque formation of herpes simplex virus type 1 (HSV1) and type 2 (HSV2) was inhibited, but vesicular stomatitis virus replication was not inhibited, in GPE cells treated with CP-20,961 before infection. The ID50 concentration of CP-20,961 for HSV was about 50 micrograms/ml for 3-4 days of pretreatment. After virus adsorption and penetration, the same concentration of CP-20,961 had no effect on HSV plaque formation.

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:20:23 GMT 2025` Edited by `admin` on `Wed Apr 02 08:20:23 GMT 2025`
Record UNII	P9J7O7YNSW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AVRIDINE

Official Name

English

CP-20961

Preferred Name

English

CP-20,961

Code

English

avridine [INN]

Common Name

English

ETHANOL, 2,2'-((3-(DIOCTADECYLAMINO)PROPYL)IMINO)BIS-

Systematic Name

English

2,2'-((3-(DIOCTADECYLAMINO)PROPYL)IMINO)DIETHANOL

Systematic Name

English

AVRIDINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2139