ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5NO2.Al.Cl.Zr.HO.H2O
Molecular Weight	263.748
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	5

SHOW SMILES / InChI

Structure of ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

Structure Search

SMILES

O.[OH-].[Al+3].[Cl-].[Zr+4].NCC(O)=O

InChI

InChIKey=WYANSMZYIOPJFV-UHFFFAOYSA-L

InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C2H4NO2
Molecular Weight	74.0587
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Zr
Molecular Weight	91.224
Charge	4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948 Apr 8	18911341
Cardiovascular manifestations of aluminium phosphide intoxication.	1989 Sep	2632560
Plasma renin activity in shock due to aluminium phosphide poisoning.	1990 Jun	2200784
Hypermagnesemia following aluminum phosphide poisoning.	1991 Feb	2026469
Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.	1995 Nov	8559152
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.	1998 Oct	10211213
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Aluminum as a toxicant.	2002 Aug	15068131
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.	2003 Nov	14753387
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003 Sep	14552065
The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.	2004 Feb 13	14960311
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].	2004 Nov	15516810
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005 Nov	16308486
Aluminum and Alzheimer's disease, a personal perspective after 25 years.	2006	17004365
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006 Aug 30	16529821
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.	2006 Nov	17119283
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.	2010 Jul	20929055
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.	2011 Mar	21057909
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.	2012 Nov 23	23041170
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.	2013 Apr	23402729
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.	2014 Mar 25	24412238
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.	2014 Sep	24906048

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:32:04 GMT 2023` Edited by `admin` on `Fri Dec 15 17:32:04 GMT 2023`
Record UNII	P9D3YP29MY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

Official Name

English

ALUMINIUM ZIRCONIUM OCTACHLOROHYDREX GLYCINE COMPLEX

Common Name

English

ALUMINIUM ZIRCONIUM OCTACHLOROHYDREX GLY

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [INCI]

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLYCINE COMPLEX

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [USP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 350.10