Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C12H14N2O2 |
Molecular Weight | 218.2518 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O
InChI
InChIKey=CZCIKBSVHDNIDH-NSHDSACASA-N
InChI=1S/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m0/s1
Molecular Formula | C12H14N2O2 |
Molecular Weight | 218.2518 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/25527549Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19239732 | https://www.ncbi.nlm.nih.gov/pubmed/24522983
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25527549
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19239732 | https://www.ncbi.nlm.nih.gov/pubmed/24522983
L-Abrine (N-Methyl-L-Tryptophan) is an indoleamino acid produced by Abrus precatoriu that shows radical scavenging and antioxidant properties in vitro. Abrin is a toxic protein produced by the ornamental plant Abrus precatorius, and it is of concern as a biothreat agent. The small coextracting molecule N-methyl-L-tryptophan (L-abrine) is specific to members of the genus Abrus and L-Abrine concentrations in A. precatorius seeds is greater than the abrin concentrations reported in seeds. L-Abrine is found only in plants of the genus Abrus, which are used medicinally but not as food. Therefore, the presence of L-abrine is a reliable and specific indicator for the presence of abrin in food products.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2073719 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11827462 |
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Target ID: Q8TF71 Gene ID: 117247.0 Gene Symbol: SLC16A10 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11278508 |
3.1 mM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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PubMed
Title | Date | PubMed |
---|---|---|
Steroid hormone activity of flavonoids and related compounds. | 2000 Jul |
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N-methyltryptophan oxidase from Escherichia coli: reaction kinetics with N-methyl amino acid and carbinolamine substrates. | 2001 Feb 6 |
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Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
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pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase. | 2005 Mar 1 |
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The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity. | 2008 Jun |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:05:45 GMT 2023
by
admin
on
Fri Dec 15 18:05:45 GMT 2023
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Record UNII |
P57TWL22IX
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Record Status |
Validated (UNII)
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Record Version |
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