TESTOSTERONE 1,2,6,7-3H

Details

Stereochemistry	MIXED
Molecular Formula	C19H28O2
Molecular Weight	296.4569
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[3H]C1C([3H])C2=CC(=O)C([3H])C([3H])[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@H]13

InChI

InChIKey=MUMGGOZAMZWBJJ-JQSYSRDDSA-N

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1/i3T,4T,7T,9T/t3?,4?,7?,9?,14-,15-,16-,17-,18-,19-

HIDE SMILES / InChI

Molecular Formula	C19H28O2
Molecular Weight	296.4569
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	6 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/180014 | https://www.ncbi.nlm.nih.gov/pubmed/262766 | https://www.ncbi.nlm.nih.gov/pubmed/7435119 | http://www.perkinelmer.com/product/testosterone-1-2-6-7-3h-n-net370250uc

(1,2,6,7-3H)-Testosterone is a radiolabeled form of the corresponding steroid hormone. It can be used to study testosterone metabolism and androgen receptor binding in tissues.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Potency
Steroid 5-alpha-reductase 15 Target ID: CHEMBL2363075 Sources: https://www.ncbi.nlm.nih.gov/pubmed/262766 \| https://www.ncbi.nlm.nih.gov/pubmed/484635 \| https://www.ncbi.nlm.nih.gov/pubmed/7435119 \| https://www.ncbi.nlm.nih.gov/pubmed/262766	Substrate 661
Cytochrome P450 3A4 127 Target ID: CHEMBL340 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9531515	Substrate 661
Androgen Receptor 169 Target ID: CHEMBL3072 Sources: https://www.ncbi.nlm.nih.gov/pubmed/180014 \| https://www.ncbi.nlm.nih.gov/pubmed/183742	Binding Agent 1076	2.0 nM [Kd]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes.	1998-04	9531515
Testosterone processing by pituitary cells in culture: an examination of the role of 5 alpha-reduction in androgen action on the gonadotroph.	1991-01	1903002
Testosterone metabolism of fibroblasts grown from prostatic carcinoma, benign prostatic hyperplasia and skin fibroblasts.	1982-02	6174738
Sex-specific occurrence of androgen receptors in rat brain.	1976-07-10	180014
Relation of uptake and metabolism of (1,2,6,7-3H)testosterone to individual differences in sexual behavior in male guinea pigs.	1976-03-19	1252950

Sample Use Guides

In Vivo Use Guide

castrated male and female rats were given an intraperitoneal injection of 250 uCi of [1,2,6,7-3H]testosterone in 120 ul of acetone.

Route of Administration: Intraperitoneal

In Vitro Use Guide

After 24 h preincubation in serum-free Eagle's medium 199, 100-mm dishes of confluent dermal papilla cells from pubic and axillary hair follicles were incubated for 2 h with 5 nM [1,2,6,7-3H]testosterone.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:25:34 GMT 2025` Edited by `admin` on `Mon Mar 31 21:25:34 GMT 2025`
Record UNII	P57HP4MCQZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TESTOSTERONE, (1,2,6,7-3H)-

Preferred Name

English

TESTOSTERONE 1,2,6,7-3H

Common Name

English

ANDROST-4-EN-3-ONE-1,2,6,7-T4, 17-HYDROXY-, (17.BETA.)-

Systematic Name

English

TESTOSTERONE, 1,2,6,7-H-3

Common Name

English

(1,2,6,7-3H)-TESTOSTERONE

Common Name

English

Code System Code Type Description

PUBCHEM

91667979