DescriptionCurator's Comment: description was created based on several sources, including:
http://www.drugbank.ca/drugs/DB01135
Curator's Comment: description was created based on several sources, including:
http://www.drugbank.ca/drugs/DB01135
Doxacurium chloride (formerly recognized as BW938U80 or BW A938U) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia for endotracheal intubation or to facilitate mechanical ventilation. Unlike a number of other related skeletal muscle relaxants, it is rarely used adjunctively to facilitate endotracheal intubation. Doxacurium chloride is a mixture of three trans, trans stereoisomers, a dl pair [(1R,1'R ,2S,2'S ) and (1S,1'S ,2R,2'R )] and a meso form (1R,1'S,2S,2'R). NUROMAX binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.
Originator
Sources: http://en.academic.ru/dic.nsf/enwiki/3078883
Curator's Comment: synthesized by Mary M. Jackson and James C. Wisowaty, PhD (both chemists within the Chemical Development Laboratories at Burroughs Wellcome Co., Research Triangle Park, NC) in collaboration with John J. Savarese MD (who at the time was an anesthesiologist in the Dept. of Anesthesia, Harvard Medical School at the Massachusetts General Hospital, Boston, MA).
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2362997 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | NUROMAX Approved UseNUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle
relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical
ventilation. Launch Date1991 |
|||
Preventing | NUROMAX Approved UseNUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle
relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical
ventilation. Launch Date1991 |
Sample Use Guides
adults: An initial NUROMAX dose of 0.08 mg/kg (3 × ED95) should be reserved for instances in which a need for very prolonged neuromuscular block is anticipated.
Children:
When administered during halothane anesthesia, an initial dose of 0.03 mg/kg (ED95) produces maximum neuromuscular block in about 7 minutes (range: 5 to 11) and clinically effective block for an average of 30 minutes (range: 12 to 54).
Route of Administration:
Intravenous
Substance Class |
Mixture
Created
by
admin
on
Edited
Fri Dec 15 16:28:29 GMT 2023
by
admin
on
Fri Dec 15 16:28:29 GMT 2023
|
Record UNII |
P40015Y3WW
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C66886
Created by
admin on Fri Dec 15 16:28:30 GMT 2023 , Edited by admin on Fri Dec 15 16:28:30 GMT 2023
|
||
|
WHO-ATC |
M03AC07
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
C81000
Created by
admin on Fri Dec 15 16:28:30 GMT 2023 , Edited by admin on Fri Dec 15 16:28:30 GMT 2023
|
PRIMARY | |||
|
SUB01822MIG
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
100000087526
Created by
admin on Fri Dec 15 16:28:30 GMT 2023 , Edited by admin on Fri Dec 15 16:28:30 GMT 2023
|
PRIMARY | |||
|
C049429
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
DB01135
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
P40015Y3WW
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
106791-39-3
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
2974
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
4706
Created by
admin on Fri Dec 15 16:28:29 GMT 2023 , Edited by admin on Fri Dec 15 16:28:29 GMT 2023
|
PRIMARY | |||
|
23651
Created by
admin on Fri Dec 15 16:28:30 GMT 2023 , Edited by admin on Fri Dec 15 16:28:30 GMT 2023
|
PRIMARY | RxNorm | ||
|
Doxacurium
Created by
admin on Fri Dec 15 16:28:30 GMT 2023 , Edited by admin on Fri Dec 15 16:28:30 GMT 2023
|
PRIMARY |
All of the following components must be present:
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |