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Details

Stereochemistry ACHIRAL
Molecular Formula C10H9N5O
Molecular Weight 215.2114
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KINETIN

SMILES

C(NC1=NC=NC2=C1N=CN2)C3=CC=CO3

InChI

InChIKey=QANMHLXAZMSUEX-UHFFFAOYSA-N
InChI=1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15)

HIDE SMILES / InChI
Molecular Formula C10H9N5O
Molecular Weight 215.2114
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Kinetin (6-furfuryladenine) is a biologically active natural phytochemical. It belongs to the category of cytokinins, the natural plant growth hormones that promote cell division and play role in cell differentiation. Kinetin functions as an essential growth hormone, which can influence cell growth and differentiation. It can delay and offset aging characteristics such as cell growth rate and size. It is claimed to reduce wrinkles and improve skin texture, telangiectasia, and mottled hyperpigmentation, although there is limited information to support this.

CNS Activity

CNS Active
4002
Curator's Comment: Kinetin is CNS active in animals No human data available.

Originator

Miller, C.O. et al.
1
Curator's Comment: reference retrieved from www.drugfuture.com/chemdata/kinetin.html

Approval Year

2013
589
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Phase IV
63
Unknown

Approved Use

Unknown
Primary
Basic research
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
806 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
3.35 mg/kg 1 times / day multiple, oral
dose: 3.35 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
728 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
6.7 mg/kg 1 times / day multiple, oral
dose: 6.7 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1787 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
11.1 mg/kg 1 times / day multiple, oral
dose: 11.1 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2760 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
16.8 mg/kg 1 times / day multiple, oral
dose: 16.8 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
5050 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
5135 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2778.75 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
3.35 mg/kg 1 times / day multiple, oral
dose: 3.35 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2622.25 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
6.7 mg/kg 1 times / day multiple, oral
dose: 6.7 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
10500.25 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
11.1 mg/kg 1 times / day multiple, oral
dose: 11.1 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
18660.5 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
16.8 mg/kg 1 times / day multiple, oral
dose: 16.8 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
26783.65 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
26854 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.65 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
3.35 mg/kg 1 times / day multiple, oral
dose: 3.35 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.65 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
6.7 mg/kg 1 times / day multiple, oral
dose: 6.7 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.6 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
11.1 mg/kg 1 times / day multiple, oral
dose: 11.1 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.86 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
16.8 mg/kg 1 times / day multiple, oral
dose: 16.8 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2.09 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
23.5 mg/kg 1 times / day multiple, oral
dose: 23.5 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
KINETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
31%
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/19033881/
KINETIN plasma
Homo sapiens
Doses

Doses

DosePopulationAdverse events​
0.03 % 2 times / day multiple, topical
Studied dose
Dose: 0.03 %, 2 times / day
Route: topical
Route: multiple
Dose: 0.03 %, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/18047609/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/18047609/
Sources:
https://pubmed.ncbi.nlm.nih.gov/18047609/
0.1 % 2 times / day multiple, topical
Studied dose
Dose: 0.1 %, 2 times / day
Route: topical
Route: multiple
Dose: 0.1 %, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17868391/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17868391/
Sources:
https://pubmed.ncbi.nlm.nih.gov/17868391/
PubMed

PubMed

TitleDatePubMed
Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia.
2010-12-20
Acetazolamide-based fungal chitinase inhibitors.
2010-12-01
Chloroplast transformation of rapeseed (Brassica napus) by particle bombardment of cotyledons.
2010-04
Neuropharmacology of vestibular system disorders.
2010-03
Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation.
2010-01-24
The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines.
2009-04-01
Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea.
2007-11
Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro.
2006-05
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
2004-11-12
"Action-at-a distance" of a new DNA oxidative damage product 6-furfuryl-adenine (kinetin) on template properties of modified DNA.
2003-02-20
N6-furfuryladenine (kinetin) hydrochloride.
2003-01
Patents

Patents

US2903455
1

Sample Use Guides

In Vitro Use Guide
addition of 40-200 uM kinetin in the culture medium of human diploid fibroblasts can both delay the onset and decrease the extent of many of the aging characteristics that appear during serial passaging of normal cells in culture.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:36:46 GMT 2025
Edited
by admin
on Mon Mar 31 18:36:46 GMT 2025
Record UNII
P39Y9652YJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KINETIN
HSDB   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
NSC-23119
Preferred Name English
6-(FURFURYLAMINO)PURINE
Systematic Name English
FURFURYL(PURIN-6-YL)AMINE
Systematic Name English
KINETIN [HSDB]
Common Name English
N(SUP 6)-FURFURYLADENINE
Systematic Name English
KINETIN [MI]
Common Name English
Kinetin [WHO-DD]
Common Name English
N6-FURFURYLADENINE
Systematic Name English
KINETIN [MART.]
Common Name English
N-(2-FURANYLMETHYL)-1H-PURIN-6-AMINE
Systematic Name English
1H-PURIN-6-AMINE, N-(2-FURANYLMETHYL)-
Systematic Name English
6-FURFURYLADENINE
Systematic Name English
6-FURFURYLAMINOPURINE
Systematic Name English
ADENINE, N-FURFURYL-
Systematic Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 116802
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
Code System Code Type Description
SMS_ID
100000166709
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
EPA CompTox
DTXSID9035175
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
CAS
525-79-1
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
MERCK INDEX
m6629
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY Merck Index
ALANWOOD
kinetin
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
DAILYMED
P39Y9652YJ
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
DRUG BANK
DB11336
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
RXCUI
16054
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY RxNorm
HSDB
7429
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
PUBCHEM
3830
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
WIKIPEDIA
KINETIN
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
ECHA (EC/EINECS)
208-382-2
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
NSC
23119
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
CHEBI
27407
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
DRUG CENTRAL
3976
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
FDA UNII
P39Y9652YJ
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
EVMPD
SUB180914
Created by admin on Mon Mar 31 18:36:46 GMT 2025 , Edited by admin on Mon Mar 31 18:36:46 GMT 2025
PRIMARY
NIH
NCATS
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