ANTIMONY TRIOXIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	3O.2Sb
Molecular Weight	291.518
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[O--].[O--].[O--].[Sb+3].[Sb+3]

InChI

InChIKey=GHPGOEFPKIHBNM-UHFFFAOYSA-N

InChI=1S/3O.2Sb/q3*-2;2*+3

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count	MOL RATIO 3 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count	MOL RATIO 2 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATP-dependent 6-phosphofructokinase 21	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schistosomiasis 32	Curative		Approved 8,429	Fuadin
Unknown 2,578

PubMed

Show entries

Title	Date	PubMed
Laboratory studies on the joint effects of certain tris (p-aminophenyl) carbonium salts and antimonials as antischistosomal drugs.	1965	5295139
Antimony impairs nucleotide excision repair: XPA and XPE as potential molecular targets.	2010 Jul 19	20509621
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes.	2012 Jul	22520151

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Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	P217481X5E
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

ANTIMONY TRIOXIDE

Common Name

English

ANTIMONIUM OXYDATUM [HPUS]

Common Name

English

ANTIMONIUM OXYDATUM

Common Name

English

NCI-C55152

Common Name

English

ANTIMONY OXIDE (SB2O3)

Common Name

English

Showing 1 to 5 of 9 entries

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Code System

Code

Type

Description

HSDB

436

PRIMARY

ECHA (EC/EINECS)

215-175-0

PRIMARY

MERCK INDEX

m1969

PRIMARY

Merck Index

RXCUI

2477431

PRIMARY

PUBCHEM

14794

PRIMARY

Showing 1 to 5 of 13 entries

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Related Record

Type

Details


					069647RPT5

ANTIMONY CATION (3+)

PARENT -> SALT/SOLVATE

Showing 1 to 1 of 1 entries

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SMILES

InChI

Originator

Approval Year

Targets

Conditions

PubMed

Patents

Sample Use Guides