PENCICLOVIR SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14N5O3.Na
Molecular Weight	275.2396
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].NC1=NC2=C(N=CN2CCC(CO)CO)C(=O)[N-]1

InChI

InChIKey=NMQFQBOIHUIALG-UHFFFAOYSA-M

InChI=1S/C10H15N5O3.Na/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17;/h5-6,16-17H,1-4H2,(H3,11,13,14,18);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C10H14N5O3
Molecular Weight	252.2499
Charge	-1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3040998 | http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/2754699

Penciclovir (DENAVIR®) is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In cells infected with HSV-1 or HSV-2, the viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted by cellular kinases to the active form penciclovir triphosphate. Biochemical studies demonstrate that penciclovir triphosphate inhibits HSV polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited. Famciclovir (FAMVIR®) is a prodrug form of penciclovir with improved oral bioavailability.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Human herpesvirus 1 DNA polymerase 19 Target ID: CHEMBL1872 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf	Inhibitor 8297		16.0 µM [Ki]
DNA polymerase catalytic subunit 14 Target ID: P89453 Gene ID: 1487316.0 Gene Symbol: NA Target Organism: Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus\|\|\|2) Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf	Inhibitor 8297		9.5 µM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Recurrent herpes labialis 3 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf	Primary		Approved 8429	DENAVIR Approved Use DENAVIR® is a nucleoside analog HSV DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in adults and children 12 years of age and older. Launch Date 1996

C_max

Value	Dose	Analyte	Population
0 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf	1.8 mg single, topical dose: 1.8 mg route of administration: Topical experiment type: SINGLE co-administered:	PENCICLOVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
0 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020629s016lbl.pdf	1.8 mg 1 times / day steady-state, topical dose: 1.8 mg route of administration: Topical experiment type: STEADY-STATE co-administered:	PENCICLOVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
6.6 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.6 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
3.3 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN
0.9 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	125 mg single, oral dose: 125 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
17.9 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4.48 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8.95 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
12.1 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN
2.24 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	125 mg single, oral dose: 125 mg route of administration: Oral experiment type: SINGLE co-administered:	PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.3 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		PENCICLOVIR unknown	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
1 % 12 times / day multiple, topical Recommended Dose: 1 %, 12 times / day Route: topical Route: multiple Dose: 1 %, 12 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020629Orig1s000rev.pdf Page: Study 024	unhealthy, 39 n = 782 Health Status: unhealthy Condition: Recurrent Herpes Simplex Labialis Age Group: 39 Sex: M+F Population Size: 782 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020629Orig1s000rev.pdf Page: Study 024	Disc. AE: Dissociative disorder... AEs leading to discontinuation/dose reduction: Dissociative disorder Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020629Orig1s000rev.pdf Page: Study 024
750 mg 3 times / day multiple, oral MTD Dose: 750 mg, 3 times / day Route: oral Route: multiple Dose: 750 mg, 3 times / day Sources: https://www.medsafe.govt.nz/Profs/Datasheet/a/APOHEALTHFamciclovirOncetab.pdf https://www.ema.europa.eu/en/documents/referral/famvir-article-30-referral-assessment-report_en.pdf	unhealthy Health Status: unhealthy Condition: Herpes zoster Sources: https://www.medsafe.govt.nz/Profs/Datasheet/a/APOHEALTHFamciclovirOncetab.pdf https://www.ema.europa.eu/en/documents/referral/famvir-article-30-referral-assessment-report_en.pdf	Sources: https://www.medsafe.govt.nz/Profs/Datasheet/a/APOHEALTHFamciclovirOncetab.pdf https://www.ema.europa.eu/en/documents/referral/famvir-article-30-referral-assessment-report_en.pdf
1500 mg single, oral Recommended Dose: 1500 mg Route: oral Route: single Dose: 1500 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Herpes labialis Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf Page: p.1	Other AEs: Acute renal failure... Other AEs: Acute renal failure Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf Page: p.1

AEs

AE	Significance	Dose	Population
Dissociative disorder	Disc. AE	1 % 12 times / day multiple, topical Recommended Dose: 1 %, 12 times / day Route: topical Route: multiple Dose: 1 %, 12 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020629Orig1s000rev.pdf Page: Study 024	unhealthy, 39 n = 782 Health Status: unhealthy Condition: Recurrent Herpes Simplex Labialis Age Group: 39 Sex: M+F Population Size: 782 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020629Orig1s000rev.pdf Page: Study 024
Acute renal failure		1500 mg single, oral Recommended Dose: 1500 mg Route: oral Route: single Dose: 1500 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Herpes labialis Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020363s037lbl.pdf Page: p.1

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1587

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
MATE2 263 OCT2 647 MATE1 306	aldehyde oxidase 16 esterase 72 CYP 270 OAT2 115 OATP1B1 406 OATP1B3 350 OATP2B1 104 NTCP 17 OCT1 327	OCT2 6 MATE2 5 MATE1 6

Drug as perpetrator

Target	Modality	Activity
CYP3A4 1925	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020363s050lbl.pdf#page=6 Page: 6.0	no
MATE1 308	inducer 1573 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	no
MATE1 308	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	no
MATE2 263	inducer 1573 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	no
OCT2 648	inducer 1573 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	no
OCT2 648	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	no
MATE2 263	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792735/	yes

Drug as victim

Target	Modality	Activity
CYP 270	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/20-363S-019_review.pdf#page=7 Page: 7.0	no
NTCP 17	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	no
OATP1B1 406	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	no
OATP1B3 350	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	no
OATP2B1 104	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	no
OCT1 327	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	no
CYP 270	substrate 3367 Sources: https://pdf.hres.ca/dpd_pm/00029892.PDF#page=13 Page: 13.0	yes
OAT2 115	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/28945155/	yes
aldehyde oxidase 16	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/9224775/	yes
esterase 72	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/27298339/	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:4974	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4974
ChEBI	CHEBI:7956	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7956
ChemicalBook	CB0464901	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB0464901
ChemicalBook	CB7731886	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7731886
MolPort	MolPort-003-666-602	https://www.molport.com/shop/molecule-link/MolPort-003-666-602
MolPort	MolPort-003-849-798	https://www.molport.com/shop/molecule-link/MolPort-003-849-798
MolPort	MolPort-006-167-513	https://www.molport.com/shop/molecule-link/MolPort-006-167-513
Selleck Chemicals	Famciclovir(Famvir)	http://www.selleckchem.com/products/Famciclovir(Famvir).html
Selleck Chemicals	penciclovir	http://www.selleckchem.com/products/penciclovir.html
ZINC	ZINC000000001899	http://zinc15.docking.org/substances/ZINC000000001899
ZINC	ZINC000001530635	http://zinc15.docking.org/substances/ZINC000001530635
eMolecules	32456333	https://www.emolecules.com/cgi-bin/more?vid=32456333
eMolecules	901871	https://www.emolecules.com/cgi-bin/more?vid=901871
eMolecules	902282	https://www.emolecules.com/cgi-bin/more?vid=902282

PubMed

Title	Date	PubMed
In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.	1992 Sep	1329640
Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells.	2001 May	12959326
Studies on the thermal decomposition process and kinetics of purine drugs.	2002 Aug	12567782
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.	2002 Aug 29	12175901
Antiviral agents: Non-antiretroviral [correction of Nonantiviral] drugs.	2002 Oct	12271305
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.	2002 Sep	12187266
[4'-Thio-5-ethyl-2'-deoxyuridine 5'-phosphonates: synthesis and antiviral activity].	2002 Sep-Oct	12408030
Current and potential therapies for the treatment of herpes-virus infections.	2003	12790345
MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.	2003 Apr 1	12640659
Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.	2003 Apr 15	12702563
Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis.	2003 Apr 15	12696003
Review of antiviral therapy for herpes labialis, genital herpes and herpes zoster.	2003 Aug	15482124
Novel agents and strategies to treat herpes simplex virus infections.	2003 Feb	12556212
In vitro activity of potential anti-poxvirus agents.	2003 Jan	12615301
Herpes simplex virus resistance to antiviral drugs.	2003 Jan	12589832
Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.	2003 Jun	12760870
The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis.	2003 Mar	12653734
Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing.	2003 May	12861349
Optimization of cellular nucleotide extraction and sample preparation for nucleotide pool analyses using capillary electrophoresis.	2003 May 5	12668076
Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection.	2003 Nov	14579096
Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials.	2003 Sep	14505088
Recurrent herpes simplex labialis: selected therapeutic options.	2003 Sep	12954137
Changing paradigms in dermatology: antivirals in dermatology.	2003 Sep-Oct	14678723
Valacyclovir in the treatment of herpes simplex, herpes zoster, and other viral infections.	2003 Sep-Oct	14505192
Inhibition of sickling in vitro by three purine-based antiviral agents: an approach to the treatment of sickle cell disease.	2003 Sep-Oct	12972037
In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1.	2004 Apr	15077679
Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial.	2004 Apr	15018852
Synthesis and biological evaluation of novel tert-azido or tert-amino substituted penciclovir analogs.	2004 Apr 21	15064793
Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study.	2004 Aug-Sep	15512970
Can clinical trials requiring frequent participant contact be conducted over the Internet? Results from an online randomized controlled trial evaluating a topical ointment for herpes labialis.	2004 Feb 17	15111272
Therapeutic options for herpes labialis, II: Topical agents.	2004 Jul	15293698
Antiviral drugs in current clinical use.	2004 Jun	15125867
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?	2004 Mar	15168799
Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques.	2004 Mar 10	15019028
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.	2004 Mar 19	14985094
Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient.	2004 May	15042649
Topical treatment of herpes labialis.	2004 Nov	15605969
Recent clinical experience with famciclovir--a "third generation" nucleoside prodrug.	2004 Sep	15535046
Penciclovir cream--improved topical treatment for herpes simplex infections.	2004 Sep-Oct	15452407
Drugs for non-HIV viral infections.	2005 Apr	15767977
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster.	2005 Aug	16045762
Agents and strategies in development for improved management of herpes simplex virus infection and disease.	2005 Feb	15757392
Recurrent antiviral-resistant genital herpes in an immunocompetent patient.	2005 Jul 1	15942905
Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.	2005 Jul-Aug	16041591
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.	2005 Mar	15728906
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.	2005 Mar	15728896
Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition.	2005 May 5	15857142
Development and validation of a new reversed-phase ion pairing liquid chromatographic method with fluorescence detection for penciclovir analysis in plasma and aqueous humor.	2005 Nov 5	16140045
Clinic-initiated, twice-daily oral famciclovir for treatment of recurrent genital herpes: a randomized, double-blind, controlled trial.	2005 Oct 15	16163627
In vitro activity of cycloSal-nucleoside monophosphates and polyhydroxycarboxylates against orthopoxviruses.	2005 Sep	16076502

Patents

Sample Use Guides

In Vivo Use Guide

Penciclovir (DENAVIR®) should be applied every 2 hours during waking hours for a period of 4 days. Treatment should be started as early as possible (i.e., during the prodrome or when lesions appear).

Route of Administration: Topical

In Vitro Use Guide

In cell culture studies, penciclovir has antiviral activity against the following herpes viruses: HSV-1 and HSV-2. The antiviral activity of penciclovir against wild type strains grown on human foreskin fibroblasts was assessed with a plaque reduction assay and staining with crystal violet 3 days postinfection for HSV. The median EC50 values of penciclovir against laboratory and clinical isolates of HSV-1 and HSV-2 were 2 uM (range 1.2 to 2.4 uM, n=7) and 2.6 uM (range 1.6 to 11 uM, n=6), respectively.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:30:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:30:09 GMT 2023`
Record UNII	P06226385L
Record Status	`Validated (UNII)`
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Name

Type

Language

PENCICLOVIR SODIUM

Official Name

English

PENCICLOVIR SODIUM [ORANGE BOOK]

Common Name

English

6H-PURIN-6-ONE, 2-AMINO-1,9-DIHYDRO-9-(4-HYDROXY-3-(HYDROXYMETHYL)BUTYL)-, SODIUM SALT (1:1)

Systematic Name

English

2-AMINO-1,9-DIHYDRO-9-(4-HYDROXY-3-(HYDROXYMETHYL)BUTYL)-6H-PURIN-6-ONE MONOSODIUM SALT

Common Name

English

9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine monosodium salt

Common Name

English

BRL-39123-D

Code

English

Penciclovir sodium [WHO-DD]

Common Name

English

PENCICLOVIR SODIUM [USAN]

Common Name

English

SODIUM PENCICLOVIR

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29575