Details
Stereochemistry | ACHIRAL |
Molecular Formula | Be |
Molecular Weight | 9.0122 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Be]
InChI
InChIKey=RWASOQSEFLDYLC-UHFFFAOYSA-N
InChI=1S/Be.2H
Molecular Formula | Be |
Molecular Weight | 9.0122 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Beryllium is a chemical element in the periodic table that has the symbol Be and atomic number 4. A toxic bivalent element, beryllium is a steel grey, strong, light-weight yet brittle, alkaline earth metal. Beryllium is an ubiquitous element in the environment, and it has many commercial applications. Beryllium is used in alloys with copper or nickel to make gyroscopes, springs, electrical contacts, spot-welding electrodes and non-sparking tools. Mixing beryllium with these metals increases their electrical and thermal conductivity. Other beryllium alloys are used as structural materials for high-speed aircraft, missiles, spacecraft and communication satellites. Beryllium is relatively transparent to X-rays so ultra-thin beryllium foil is finding use in X-ray lithography. Beryllium is also used in nuclear reactors as a reflector or moderator of neutrons. Beryllium and its compounds are toxic and carcinogenic. If beryllium dust or fumes are inhaled, it can lead to an incurable inflammation of the lungs called berylliosis. Because it is strong, stable, can handle elevated levels of heat resistance and is highly transparent to x-rays, beryllium, in thin foil form, has long been critical to the operation of medical and scientific x-ray equipment. Beryllium foil provides the window through which tissue-penetrating x-rays are focused, while maintaining the vacuum inside the x-ray tube generator. Beryllium foil remains indispensible for high-resolution medical radiography, including CT scanning and mammography. Beryllium in newer generation mammography equipment enables a lower radiation dose scan with significantly finer tumor resolution, enabling breast cancer detection at its early, most treatable stages. Beryllium is also used in components of the analytical equipment used to analyze blood for HIV and other diseases, offering the precision and reliability that doctors and patients demand.
Approval Year
PubMed
Title | Date | PubMed |
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Tumor necrosis factor alpha gene expression in human monocytic THP-1 cells exposed to beryllium. | 1996 Jan-Feb |
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Animal models of beryllium-induced lung disease. | 1996 Oct |
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Chronic granulomatous pneumonia and lymphocytic responses induced by inhaled beryllium metal in A/J and C3H/HeJ mice. | 1997 Jan-Feb |
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Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens. | 2002 Feb |
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Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity. | 2002 Mar 15 |
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The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization. | 2004 Aug |
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Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells. | 2006 Sep 15 |
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Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. | 2008 Jul 6 |
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Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. | 2009 Sep |
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Crystal structure of HLA-DP2 and implications for chronic beryllium disease. | 2010 Apr 20 |
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Metal ions affecting the skin and eyes. | 2011 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5499975
The incorporation of thymidine into DNA of regenerating rat liver was measured at various times after partial hepatectomy. A single intravenous injection of 30 umol of beryllium/kg given immediately after the operation inhibited DNA synthesis 12, 16, 20, 24 and 28h later.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
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Record UNII |
OW5102UV6N
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Record Status |
Validated (UNII)
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DSLD |
239 (Number of products:23)
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NCI_THESAURUS |
C45383
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C637
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76654-3
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33783
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5460467
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231-150-7
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m2433
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30501
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C44338
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OW5102UV6N
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52628
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Beryllium
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OW5102UV6N
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