Tebapivat

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16N8OS
Molecular Weight	392.438
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(SC(CC3=NNC=C3)=N2)C4=C1C(=O)N(CC5=CC=CC(N)=N5)N=C4

InChI

InChIKey=DIUOELXIXSCFCR-UHFFFAOYSA-N

InChI=1S/C18H16N8OS/c1-25-15-12(16-17(25)23-14(28-16)7-10-5-6-20-24-10)8-21-26(18(15)27)9-11-3-2-4-13(19)22-11/h2-6,8H,7,9H2,1H3,(H2,19,22)(H,20,24)

HIDE SMILES / InChI

Molecular Formula	C18H16N8OS
Molecular Weight	392.438
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
38.2 ng/mL EXPERIMENT https://www.agios.com/wp-content/uploads/2021/12/2043_AG946-HV.pdf	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		TEBAPIVAT plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
89.025 ng/mL EXPERIMENT https://www.agios.com/wp-content/uploads/2021/12/2043_AG946-HV.pdf	5 mg 1 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TEBAPIVAT plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
143.9 ng × h/mL EXPERIMENT https://www.agios.com/wp-content/uploads/2021/12/2043_AG946-HV.pdf	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		TEBAPIVAT plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
542.4 ng × h/mL EXPERIMENT https://www.agios.com/wp-content/uploads/2021/12/2043_AG946-HV.pdf	5 mg 1 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TEBAPIVAT plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:14:07 GMT 2025` Edited by `admin` on `Wed Apr 02 06:14:07 GMT 2025`
Record UNII	ORG4KGP5ZS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tebapivat

Official Name

English

5H-Thiazolo[5?,4?:4,5]pyrrolo[2,3-d]pyridazin-5-one, 6-[(6-amino-2-pyridinyl)methyl]-4,6-dihydro-4-methyl-2-(1H-pyrazol-3-ylmethyl)-

Preferred Name

English

6-[(6-Amino-2-pyridinyl)methyl]-4,6-dihydro-4-methyl-2-(1H-pyrazol-3-ylmethyl)-5H-thiazolo[5?,4?:4,5]pyrrolo[2,3-d]pyridazin-5-one

Systematic Name

English

TEBAPIVAT [USAN]

Common Name

English

AG-946

Common Name

English

AGI-44416

Common Name

English

2-((1H-pyrazol-3-yl)methyl)-6-((6-aminopyridin-2-yl)methyl)-4-methyl-4H-thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Systematic Name

English

tebapivat [INN]

Common Name

English

Code System Code Type Description

PUBCHEM

137501615