VEDAPROFEN

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22O2
Molecular Weight	282.3768
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC(C(O)=O)C1=CC=C(C2CCCCC2)C3=C1C=CC=C3

InChI

InChIKey=VZUGVMQFWFVFBX-UHFFFAOYSA-N

InChI=1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C19H22O2
Molecular Weight	282.3768
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Vedaprofen is a PGE2 synthase inhibitor approved in Europe for the treatment of pain in horses and dogs.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 48	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614	Primary		Approved 8,429	QUADRISOL

PubMed

PubMed

Show entries

Title	Date	PubMed
Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy.	2007 Feb	17286658
Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.	2008 Feb	17408711
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats.	2009 Jun	19168382
Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme.	2010 Dec	19515030

Showing 1 to 4 of 4 entries

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Sample Use Guides

In Vivo Use Guide

Twice daily administration. An initial dose of 2 mg/kg (2.0 ml/100 kg) is followed by a maintenance dose of 1 mg/kg (1.0 ml/100 kg) given every 12 hours. Treatment can be continued for a maximum of 14 consecutive days.

Route of Administration: Oral

In Vitro Use Guide

Unknown