VEDAPROFEN

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22O2
Molecular Weight	282.3768
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C(O)=O)C1=CC=C(C2CCCCC2)C3=C1C=CC=C3

InChI

InChIKey=VZUGVMQFWFVFBX-UHFFFAOYSA-N

InChI=1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C19H22O2
Molecular Weight	282.3768
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/veterinary/000032/WC500067567.pdf

Vedaprofen is a PGE2 synthase inhibitor approved in Europe for the treatment of pain in horses and dogs.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 48 Target ID: O19183 Gene ID: 791253.0 Gene Symbol: PTGS2 Target Organism: Equus caballus (Horse) Sources: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/veterinary/000032/WC500067567.pdf	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/veterinary/000032/WC500067563.pdf	Primary		Approved 8429	QUADRISOL Approved Use Reduction of inflammation and relief of pain associated with musculo-skeletal disorders and soft tissue lesions (traumatic injuries and surgical trauma). Launch Date 1997

PubMed

Title	Date	PubMed
Influence of vedaprofen (Quadrisol) on quality and freezability of stallion semen.	2005 Nov	15955550
Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy.	2007 Feb	17286658

Sample Use Guides

In Vivo Use Guide

Twice daily administration. An initial dose of 2 mg/kg (2.0 ml/100 kg) is followed by a maintenance dose of 1 mg/kg (1.0 ml/100 kg) given every 12 hours. Treatment can be continued for a maximum of 14 consecutive days.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:37:59 GMT 2023` Edited by `admin` on `Fri Dec 15 16:37:59 GMT 2023`
Record UNII	OKX88EO7OI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VEDAPROFEN

Official Name

English

CERM10202

Code

English

VEDAPROFEN FOR VETERINARY USE

Common Name

English

1-NAPHTHALENEACETIC ACID, 4-CYCLOHEXYL-.ALPHA.-METHYL-, (±)-

Common Name

English

VEDAPROFEN [MI]

Common Name

English

CERM-10202

Code

English

VEDAPROFEN [JAN]

Common Name

English

1-NAPHTHALENEACETIC ACID, 4-CYCLOHEXYL-.ALPHA.-METHYL-

Common Name

English

VEDAPROFEN [EMA EPAR VETERINARY]

Common Name

English

vedaprofen [INN]

Common Name

English

VEDAPROFEN [USAN]

Common Name

English

VEDAPROFEN FOR VETERINARY USE [EP MONOGRAPH]

Common Name

English

PM-150

Code

English

QUADRISOL

Brand Name

English

PM150

Code

English

VEDAPROFEN [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM01AE90