NORMETHADONE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO.ClH
Molecular Weight	331.88
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

Cl.CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=GYWUCVKLUKFJLC-UHFFFAOYSA-N

InChI=1S/C20H25NO.ClH/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14H,4,15-16H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61	Agonist 2,752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106	Primary		Approved 8,583	Cophylac

Doses

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Dose	Population	Adverse events
100 mg single, oral Overdose	healthy, CHILD	Disc. AE: Hyporeflexia, Coma...
15 drop 2 times / day multiple, oral Recommended	unhealthy, CHILD\|ADOLESCENT\|ADULT	Disc. AE: Opioid abuse, Opioid type dependence...

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AEs

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AE	Significance	Dose	Population
Coma	Disc. AE	100 mg single, oral Overdose	healthy, CHILD
Disseminated intravascular coagulation	Disc. AE	100 mg single, oral Overdose	healthy, CHILD
Fever	Disc. AE	100 mg single, oral Overdose	healthy, CHILD
Hepatocellular injury	Disc. AE	100 mg single, oral Overdose	healthy, CHILD
Hyporeflexia	Disc. AE	100 mg single, oral Overdose	healthy, CHILD

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PubMed

PubMed

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Title	Date	PubMed
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009 Apr 15	19232849

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Sample Use Guides

In Vivo Use Guide

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	OIV53II16G
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

COPHYLAC COMPONENT NORMETHADONE HYDROCHLORIDE

Preferred Name

English

NORMETHADONE HYDROCHLORIDE

Common Name

English

ISOAMIDONE I HYDROCHLORIDE

Common Name

English

NORMETHADONE HYDROCHLORIDE [MI]

Common Name

English

Normethadone hydrochloride [WHO-DD]

Common Name

English

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Code System

Code

Type

Description

EVMPD

SUB03461MIG

PRIMARY

DRUG BANK

DBSALT001919

PRIMARY

PUBCHEM

13312

PRIMARY

EPA CompTox

DTXSID60233711

PRIMARY

ECHA (EC/EINECS)

212-694-4

PRIMARY

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					KR2L2A68XL

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SALT/SOLVATE -> PARENT


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NORMETHADONE

SALT/SOLVATE -> PARENT


					KR2L2A68XL

NORMETHADONE

PARENT -> SALT/SOLVATE

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Show entries

Related Record

Type

Details


					KR2L2A68XL

NORMETHADONE

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

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SMILES

InChI

Description<div class="info-popup-container"><div><span class="pop-sub-key ">Sources:&nbsp;</span><span class="pop-sub-val"><span class="ext-link"><a target="_self" href="http://www.rexall.ca/articles/view/1486/Cophylac">http://www.rexall.ca/articles/view/1486/Cophylac</a></span></span></div></div>

CNS Activity

Approval Year

Targets

Conditions

Doses

AEs

PubMed

Sample Use Guides

Description