NORMETHADONE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO.ClH
Molecular Weight	331.88
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=GYWUCVKLUKFJLC-UHFFFAOYSA-N

InChI=1S/C20H25NO.ClH/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14H,4,15-16H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.rexall.ca/articles/view/1486/Cophylac

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P33535\|\|\|Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) Sources: http://www.ncbi.nlm.nih.gov/pubmed/7602488	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://www.rexall.ca/articles/view/1486/Cophylac	Primary		Approved 8429	Cophylac Approved Use Cough

PubMed

Title	Date	PubMed
Phenyl-substituted normethadones: synthesis and pharmacology.	1995 Mar	7602488
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009 Apr 15	19232849

Sample Use Guides

In Vivo Use Guide

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:02:09 GMT 2023` Edited by `admin` on `Fri Dec 15 19:02:09 GMT 2023`
Record UNII	OIV53II16G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORMETHADONE HYDROCHLORIDE

Common Name

English

ISOAMIDONE I HYDROCHLORIDE

Common Name

English

NORMETHADONE HYDROCHLORIDE [MI]

Common Name

English

COPHYLAC COMPONENT NORMETHADONE HYDROCHLORIDE

Brand Name

English

NORMETHADONE HYDROCHLORIDE COMPONENT OF COPHYLAC

Brand Name

English

Normethadone hydrochloride [WHO-DD]

Common Name

English

UM 118

Code

English

DACARTIL HYDROCHLORIDE

Common Name

English

3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE

Systematic Name

English

NIH-10385

Code

English

6-DIMETHYLAMINO-4,4-DIPHENYLHEXAN-3-ONE HYDROCHLORIDE

Systematic Name

English

NORMETHADONE HYDROCHLORIDE [MART.]

Common Name

English

DESMETHYLMETHADONE HYDROCHLORIDE

Common Name

English

TICARDA

Brand Name

English

MCV-4457

Code

English

Code System Code Type Description

EVMPD

SUB03461MIG