U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H25NO.ClH
Molecular Weight 331.88
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORMETHADONE HYDROCHLORIDE

SMILES

Cl.CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=GYWUCVKLUKFJLC-UHFFFAOYSA-N
InChI=1S/C20H25NO.ClH/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14H,4,15-16H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula C20H25NO
Molecular Weight 295.4186
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P33535|||Q64064
Gene ID: 25601.0
Gene Symbol: Oprm1
Target Organism: Rattus norvegicus (Rat)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Cophylac

Approved Use

Cough
PubMed

PubMed

TitleDatePubMed
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.
2009 Apr 15

Sample Use Guides

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:02:09 GMT 2023
Edited
by admin
on Fri Dec 15 19:02:09 GMT 2023
Record UNII
OIV53II16G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NORMETHADONE HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
ISOAMIDONE I HYDROCHLORIDE
Common Name English
NORMETHADONE HYDROCHLORIDE [MI]
Common Name English
COPHYLAC COMPONENT NORMETHADONE HYDROCHLORIDE
Brand Name English
NORMETHADONE HYDROCHLORIDE COMPONENT OF COPHYLAC
Brand Name English
Normethadone hydrochloride [WHO-DD]
Common Name English
UM 118
Code English
DACARTIL HYDROCHLORIDE
Common Name English
3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE
Systematic Name English
NIH-10385
Code English
6-DIMETHYLAMINO-4,4-DIPHENYLHEXAN-3-ONE HYDROCHLORIDE
Systematic Name English
NORMETHADONE HYDROCHLORIDE [MART.]
Common Name English
DESMETHYLMETHADONE HYDROCHLORIDE
Common Name English
TICARDA
Brand Name English
MCV-4457
Code English
Code System Code Type Description
EVMPD
SUB03461MIG
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
DRUG BANK
DBSALT001919
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
PUBCHEM
13312
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID60233711
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
ECHA (EC/EINECS)
212-694-4
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
MESH
C005845
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
SMS_ID
100000085723
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
MERCK INDEX
m8068
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY Merck Index
CAS
847-84-7
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
FDA UNII
OIV53II16G
Created by admin on Fri Dec 15 19:02:09 GMT 2023 , Edited by admin on Fri Dec 15 19:02:09 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY