NORMETHADONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO
Molecular Weight	295.4186
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NORMETHADONE

Structure Search

SMILES

CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=WCJFBSYALHQBSK-UHFFFAOYSA-N

InChI=1S/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.rexall.ca/articles/view/1486/Cophylac

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P33535\|\|\|Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) Sources: http://www.ncbi.nlm.nih.gov/pubmed/7602488	Agonist 2678

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://www.rexall.ca/articles/view/1486/Cophylac	Primary		Approved 8429	Cophylac Approved Use Cough

PubMed

PubMed

Title	Date	PubMed
Phenyl-substituted normethadones: synthesis and pharmacology.	1995 Mar	7602488
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009 Apr 15	19232849

Sample Use Guides

In Vivo Use Guide

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:33:06 GMT 2023` Edited by `admin` on `Fri Dec 15 16:33:06 GMT 2023`
Record UNII	KR2L2A68XL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NORMETHADONE

Official Name

English

1,1-DIPHENYL-1-(2-DIMETHYLAMINOETHYL)-2-BUTANONE

Systematic Name

English

NORMETHADONE [MI]

Common Name

English

normethadone [INN]

Common Name

English

6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEXANONE

Systematic Name

English

HOECHST-10582

Code

English

MEPIDON

Common Name

English

ISOMETHADONE I

Common Name

English

HOECHST 10582

Code

English

IDS-NN-007

Code

English

J5.915C

Code

English

NSC-19598

Code

English

Normethadone [WHO-DD]

Common Name

English

EUCOPON

Common Name

English

Classification Tree Code System Code

DEA NO.

9635

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

WHO-ATC

R05DA06

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

NCI_THESAURUS

C67413

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

WHO-VATC

QR05DA06

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

Code System Code Type Description

RXCUI

32009

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

RxNorm

EPA CompTox

DTXSID6057748

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

NCI_THESAURUS

C76843

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

WIKIPEDIA

NORMETHADONE

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

Normethadone (INN, BAN; brand names Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent.Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is an Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams.

DRUG CENTRAL

1969

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

FDA UNII

KR2L2A68XL

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

NSC

19598

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

INN

467

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

ECHA (EC/EINECS)

207-401-1

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

EVMPD

SUB09376MIG

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

MERCK INDEX

m8068

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

Merck Index

CAS

467-85-6

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

SMS_ID

100000083620

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

PUBCHEM

10090

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

DRUG BANK

DB11609

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

MESH

C005845

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

ChEMBL

CHEMBL346331

Created by admin on Fri Dec 15 16:33:06 GMT 2023 , Edited by admin on Fri Dec 15 16:33:06 GMT 2023

PRIMARY

Related Record Type Details


					3R57N9908J

NORMETHADONE OXALATE

PARENT -> SALT/SOLVATE


					OIV53II16G

NORMETHADONE HYDROCHLORIDE

PARENT -> SALT/SOLVATE


					632S02T2CC

NORMETHADONE PICRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					OIV53II16G

NORMETHADONE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					06USP7T2XG

NORMETHADONE HYDROBROMIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					06USP7T2XG

NORMETHADONE HYDROBROMIDE

PARENT -> SALT/SOLVATE


					3R57N9908J

NORMETHADONE OXALATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

Related Record Type Details


					KR2L2A68XL

ACTIVE MOIETY