Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C35H36N4O6.Pd |
Molecular Weight | 715.1 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Pd++].CC[C@@H]1[C@@H](C)C2=CC3=C(C(C)=O)C(C)=C([N-]3)C=C4N=C([C@@H](CCC(O)=O)[C@@H]4C)C5=C6[N-]C(=CC1=N2)C(C)=C6C(=O)[C@@H]5C(=O)OC
InChI
InChIKey=GPIVNYFDHQDTDZ-GDUCSYRESA-L
InChI=1S/C35H38N4O6.Pd/c1-8-19-14(2)21-13-26-28(18(6)40)16(4)23(37-26)11-22-15(3)20(9-10-27(41)42)32(38-22)30-31(35(44)45-7)34(43)29-17(5)24(39-33(29)30)12-25(19)36-21;/h11-15,19-20,31H,8-10H2,1-7H3,(H3,36,37,38,39,40,41,42,43);/q;+2/p-2/t14-,15+,19-,20+,31-;/m1./s1
Molecular Formula | C35H37N4O6 |
Molecular Weight | 609.6915 |
Charge | -1 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | Pd |
Molecular Weight | 106.42 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Padoporfin (palladium bacteriopheophorbide, also known as WST-09) from the bacteriopheophorbide family was used as a photosensitizer in clinical trials for prostate and kidney cancers. Padoporfin successfully completed phase III clinical trial where was shown its efficacy and safety for localized prostate cancer. Padoporfin is a powerful photosensitizer that produces photodynamic therapy effects similar to those seen with longer acting drugs, but with the major advantages of a short drug-light interval and rapid clearance.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses. | 2008 Aug 5 |
|
Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician's insight. | 2016 Mar 26 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27019798
Twenty-eight patients enrolled in this trial received a padoporfin dose of 2 mg/kg and a specific radiation fluence (λ = 763 nm), established in computer-assisted treatment plan
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:38:46 GMT 2023
by
admin
on
Fri Dec 15 19:38:46 GMT 2023
|
Record UNII |
OIH1H7CJCJ
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C1420
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
||
|
NCI_THESAURUS |
C1742
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
OIH1H7CJCJ
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY | |||
|
C61321
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY | |||
|
100000175514
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY | |||
|
274679-00-4
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY | |||
|
8595
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY | |||
|
9918226
Created by
admin on Fri Dec 15 19:38:46 GMT 2023 , Edited by admin on Fri Dec 15 19:38:46 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |