SANCYCLINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H22N2O7
Molecular Weight	414.4086
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=CC=CC(O)=C3C(=O)C1=C(O)[C@]4(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]4([H])C2

InChI

InChIKey=XDVCLKFLRAWGIT-ADOAZJKMSA-N

InChI=1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24,26-27,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H22N2O7
Molecular Weight	414.4086
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: Semi-synthetic antibiotic related to tetracycline. Beereboom et al., J. Am. Chem. Soc. 82, 1003 (1960);

There is a little information around sancycline. It is known, that it was synthesized by Conover and co-workers in 1962 and it was antibacterial compound. It was proposed that sancycline binds to the 30S of bacterial ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
batcerial 30S ribosomal subunit 2 Target ID: batcerial 30S ribosomal subunit	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:01:37 GMT 2023` Edited by `admin` on `Fri Dec 15 19:01:37 GMT 2023`
Record UNII	ODN00F2SJG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SANCYCLINE

Official Name

English

GS 2147

Code

English

4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Systematic Name

English

2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, (4S,4AS,5AR,12AS)-

Systematic Name

English

GS-2147

Code

English

BONOMYCIN

Brand Name

English

SANCYCLINE [USAN]

Common Name

English

SANCYCLINE [MI]

Common Name

English

sancycline [INN]

Common Name

English

6-DEMETHYL-6-DEOXYTETRACYCLINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1595