ETHONAFIDE

CCOC1=C2C=CC=C3C(=O)N(CCN(C)C)C(=O)C(C4=CC=CC=C14)=C23

InChIKey=CQZISUJEDPJJNF-UHFFFAOYSA-N

InChI=1S/C22H22N2O3/c1-4-27-20-15-9-6-5-8-14(15)19-18-16(20)10-7-11-17(18)21(25)24(22(19)26)13-12-23(2)3/h5-11H,4,12-13H2,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis.	2007 Dec 1	18025185
Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells.	2007 Jun	17351106
Proteasomal inhibition stabilizes topoisomerase IIalpha protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide).	2008 Feb 15	18062937

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:54:30 GMT 2023` Edited by `admin` on `Sat Dec 16 09:54:30 GMT 2023`
Record UNII	OCD466V4LD
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

ETHONAFIDE

Common Name

English

AMP-53

Common Name

English

1H-DIBENZ(DE,H)ISOQUINOLINE-1,3(2H)-DIONE, 2-(2-(DIMETHYLAMINO)ETHYL)-7-ETHOXY-

Systematic Name

English

2-(2'-(DIMETHYLAMINO)ETHYL)-1,2-DIHYDRO-7-ETHOXYDIBENZ(DE, H)ISOQUINOLINE-1,3-DIONE

Common Name

English

Code System Code Type Description

PUBCHEM

10522660

Created by admin on Sat Dec 16 09:54:30 GMT 2023 , Edited by admin on Sat Dec 16 09:54:30 GMT 2023

PRIMARY

CAS

175293-23-9

Created by admin on Sat Dec 16 09:54:30 GMT 2023 , Edited by admin on Sat Dec 16 09:54:30 GMT 2023

PRIMARY

FDA UNII

OCD466V4LD

Created by admin on Sat Dec 16 09:54:30 GMT 2023 , Edited by admin on Sat Dec 16 09:54:30 GMT 2023

PRIMARY

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