ETHONAFIDE

CCOC1=C2C=CC=CC2=C3C(=O)N(CCN(C)C)C(=O)C4=C3C1=CC=C4

InChIKey=CQZISUJEDPJJNF-UHFFFAOYSA-N

InChI=1S/C22H22N2O3/c1-4-27-20-15-9-6-5-8-14(15)19-18-16(20)10-7-11-17(18)21(25)24(22(19)26)13-12-23(2)3/h5-11H,4,12-13H2,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Proteasomal inhibition stabilizes topoisomerase IIalpha protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide).	2008-02-15	18062937
Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis.	2007-12-01	18025185
Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells.	2007-06	17351106

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:54:13 GMT 2025` Edited by `admin` on `Mon Mar 31 22:54:13 GMT 2025`
Record UNII	OCD466V4LD
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

ETHONAFIDE

Common Name

English

2-(2'-(DIMETHYLAMINO)ETHYL)-1,2-DIHYDRO-7-ETHOXYDIBENZ(DE, H)ISOQUINOLINE-1,3-DIONE

Preferred Name

English

AMP-53

Common Name

English

1H-DIBENZ(DE,H)ISOQUINOLINE-1,3(2H)-DIONE, 2-(2-(DIMETHYLAMINO)ETHYL)-7-ETHOXY-

Systematic Name

English

Code System Code Type Description

PUBCHEM

10522660

Created by admin on Mon Mar 31 22:54:13 GMT 2025 , Edited by admin on Mon Mar 31 22:54:13 GMT 2025

PRIMARY

CAS

175293-23-9

Created by admin on Mon Mar 31 22:54:13 GMT 2025 , Edited by admin on Mon Mar 31 22:54:13 GMT 2025

PRIMARY

FDA UNII

OCD466V4LD

Created by admin on Mon Mar 31 22:54:13 GMT 2025 , Edited by admin on Mon Mar 31 22:54:13 GMT 2025

PRIMARY

Related Record Type Details


					OCD466V4LD

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