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Details

Stereochemistry MIXED
Molecular Formula C34H38N4O6.2ClH
Molecular Weight 671.611
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEMATOPORPHYRIN DIHYDROCHLORIDE

SMILES

Cl.Cl.CC(O)C1=C(C)C2=CC3=C(C(C)O)C(C)=C(N3)C=C4N=C(C=C5NC(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C

InChI

InChIKey=QCLJGYHFHNRFIL-UDHHKLSBSA-N
InChI=1S/C34H38N4O6.2ClH/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27;;/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44);2*1H/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-;;

HIDE SMILES / InChI
Molecular Formula C34H38N4O6
Molecular Weight 598.6887
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Hematoporphyrin (Photodyn), a porphyrin prepared from hemin, is used as a photosensitizer in photodynamic therapy. Photodynamic therapy is based on the use of light-sensitive photosensitizers. Photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death. Hematoporphyrin was used as the therapeutic agent in patients with manic-depressive reactions and in patients with involutional melancholia. One of the last studies has shown, that Hematoporphyrin-Photodynamic therapy (PDT) combined with stent placement is an effective and safe treatment for extrahepatic cholangiocarcinoma (EHCC).

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Manic-depressive disease
9
Sources: DOI: 10.1176/ajp.90.6.1157
 Primary
Not Provided
504
Unknown

Approved Use

Unknown
Involutional melancholia
4
Sources: DOI: 10.1176/ajp.90.6.1157
 Primary
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Not Provided
504
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.
1990
[Effects of quercetin on photosensitized oxidation of alpha-tocopherol in human blood cells in the presence of hematoporphyrin].
1990
Separation of lipoproteins, albumin and gamma-globulin by single-step ultracentrifugation of human serum. Application. I: Binding of hematoporphyrin to human serum and to albumin.
1995 Apr
Temperature-induced changes in fluorescence properties as a probe of porphyrin microenvironment in lipid membranes. 2. The partition of hematoporphyrin and protoporphyrin in mitochondria.
1995 Oct 1
Structural investigation of the complexation properties between horse spleen apoferritin and metalloporphyrins.
1996 Mar
[Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid].
1997 Nov
Photodynamic therapy: a new approach to prostate cancer.
2003 Jun
Interaction of porphyrins with human organic anion transporting polypeptide 1B1.
2009 Nov 10
Patents

Patents

JP2005506199A
4
JP2007178237A
4
JPH06135966A
4
JPS60201255A
4

Sample Use Guides

In Vivo Use Guide
Twenty-three patients with manic-depressive reactions were treated during the depressed phase with intramuscular and oral administration of hematoporphyrin hydrochloride for an average period of 50 to 6o days. Of this number five showed marked sustained improvement, six showed moderate sustained improvement, and six were generally benefited but the course of the psychosis did not seem to be positively affected. Six gave no favorable response. Seventeen patients of 23 can be said to have been definitely helped by the treatment
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:08:26 UTC 2023
Edited
by admin
on Sat Dec 16 05:08:26 UTC 2023
Record UNII
O535A6S0T2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HEMATOPORPHYRIN DIHYDROCHLORIDE
Common Name English
Hematoporphyrin hydrochloride [WHO-DD]
Common Name English
21H,23H-PORPHINE-2,18-DIPROPANOIC ACID, 7,12-BIS(1-HYDROXYETHYL)-3,8,13,17-TETRAMETHYL-, HYDROCHLORIDE (1:2)
Common Name English
HEMATOPORPHYRIN HYDROCHLORIDE
WHO-DD  
Common Name English
HEMATOPORPHYRIN IX DIHYDROCHLORIDE
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
241-699-4
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
EVMPD
SUB14073MIG
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
CAS
138148-89-7
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
ALTERNATIVE
EVMPD
SUB22783
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
SMS_ID
100000077892
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
EPA CompTox
DTXSID00884983
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
CAS
17696-69-4
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
FDA UNII
O535A6S0T2
Created by admin on Sat Dec 16 05:08:26 UTC 2023 , Edited by admin on Sat Dec 16 05:08:26 UTC 2023
PRIMARY
Related Record Type Details
Structure of HEMATOPORPHYRIN HYDROCHLORIDE MONOHYDRATE
SOLVATE->ANHYDROUS
Structure of HEMATOPORPHYRIN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of HEMATOPORPHYRIN
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