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Details

Stereochemistry MIXED
Molecular Formula C34H38N4O6
Molecular Weight 598.6887
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEMATOPORPHYRIN

SMILES

CC(O)C1=C(C)C2=CC3=C(C(C)O)C(C)=C(N3)C=C4N=C(C=C5NC(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C

InChI

InChIKey=UJKPHYRXOLRVJJ-AMPAVEGJSA-N
InChI=1S/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-

HIDE SMILES / InChI
Molecular Formula C34H38N4O6
Molecular Weight 598.6887
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Hematoporphyrin (Photodyn), a porphyrin prepared from hemin, is used as a photosensitizer in photodynamic therapy. Photodynamic therapy is based on the use of light-sensitive photosensitizers. Photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death. Hematoporphyrin was used as the therapeutic agent in patients with manic-depressive reactions and in patients with involutional melancholia. One of the last studies has shown, that Hematoporphyrin-Photodynamic therapy (PDT) combined with stent placement is an effective and safe treatment for extrahepatic cholangiocarcinoma (EHCC).

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Manic-depressive disease
9
Sources: DOI: 10.1176/ajp.90.6.1157
 Primary
Not Provided
504
Unknown

Approved Use

Unknown
Involutional melancholia
4
Sources: DOI: 10.1176/ajp.90.6.1157
 Primary
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Not Provided
504
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Detection and localization of In situ carcinoma of the bladder with hematoporphyrin derivative.
1982 Sep
Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.
1990
Structural investigation of the complexation properties between horse spleen apoferritin and metalloporphyrins.
1996 Mar
[Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid].
1997 Nov
Low-density lipoprotein receptors in the uptake of tumour photosensitizers by human and rat transformed fibroblasts.
2002 Jan
Photodynamic therapy: a new approach to prostate cancer.
2003 Jun
Patents

Patents

JP2005506199A
4
JP2007178237A
4
JPH06135966A
4
JPS60201255A
4

Sample Use Guides

In Vivo Use Guide
Twenty-three patients with manic-depressive reactions were treated during the depressed phase with intramuscular and oral administration of hematoporphyrin hydrochloride for an average period of 50 to 6o days. Of this number five showed marked sustained improvement, six showed moderate sustained improvement, and six were generally benefited but the course of the psychosis did not seem to be positively affected. Six gave no favorable response. Seventeen patients of 23 can be said to have been definitely helped by the treatment
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:55:48 GMT 2023
Edited
by admin
on Fri Dec 15 18:55:48 GMT 2023
Record UNII
HBT6M5H379
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HEMATOPORPHYRIN
MI   WHO-DD  
Common Name English
Hemoporfin [WHO-DD]
Common Name English
PHOTODYN
Common Name English
HEMATOPORPHYRIN [MI]
Common Name English
NSC-267084
Code English
2,4-BIS(1-HYDROXYETHYL)-1,3,5,8-TETRAMETHYL-5,7-PORPHINDIPROPIONSAEURE
Common Name English
21H,23H-PORPHINE-2,18-DIPROPANOIC ACID, 7,12-BIS(1-HYDROXYETHYL)-3,8,13,17-TETRAMETHYL-
Common Name English
NSC-59265
Code English
21H,23H-PORPHINE-2,18-DIPROPANOIC ACID, 7(OR 12)-(1-HYDROXYETHYL)-12(OR 7)-(1-METHOXYETHYL)-3,8,13,17-TETRAMETHYL-
Common Name English
Hematoporphyrin [WHO-DD]
Common Name English
HAEMATOPORPHYRIN
Common Name English
7,12-BIS(1-HYDROXYETHYL)-2,8,13,17-TETRAMETHYL-21H,23H-PORPHIN-2,18-DIPROPIONSAEURE
Common Name English
2,18-PORPHINEDIPROPIONIC ACID, 7,12-BIS(1-HYDROXYETHYL)-3,8,13,17-TETRAMETHYL-
Systematic Name English
HEMOPORFIN
Common Name English
HEMATOPORPHYRIN IX
Common Name English
7,12-BIS(1-HYDROXYETHYL)-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOIC ACID
Common Name English
Classification Tree Code System Code
LOINC 33626-3
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
Code System Code Type Description
EVMPD
SUB14072MIG
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
NSC
267084
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
EVMPD
SUB96359
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
NSC
59265
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
MERCK INDEX
m5941
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY Merck Index
CAS
553-11-7
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
SUPERSEDED
NCI_THESAURUS
C167224
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
CHEBI
36162
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID901030645
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
SMS_ID
100000077911
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
PUBCHEM
11103
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
RXCUI
5164
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY RxNorm
FDA UNII
HBT6M5H379
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
ECHA (EC/EINECS)
238-450-7
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
DRUG CENTRAL
3274
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
CAS
14459-29-1
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
WIKIPEDIA
HEMATOPORPHYRIN
Created by admin on Fri Dec 15 18:55:48 GMT 2023 , Edited by admin on Fri Dec 15 18:55:48 GMT 2023
PRIMARY
Related Record Type Details
Structure of HEMATOPORPHYRIN DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of HEMATOPORPHYRIN
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