PROMETHAZINE HYDROXYETHYL CHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25N2OS.Cl
Molecular Weight	364.933
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PROMETHAZINE HYDROXYETHYL CHLORIDE

Structure Search

SMILES

[Cl-].CC(CN1C2=C(SC3=C1C=CC=C3)C=CC=C2)[N+](C)(C)CCO

InChI

InChIKey=FUFHLEMGRBXVCF-UHFFFAOYSA-M

InChI=1S/C19H25N2OS.ClH/c1-15(21(2,3)12-13-22)14-20-16-8-4-6-10-18(16)23-19-11-7-5-9-17(19)20;/h4-11,15,22H,12-14H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C19H24N2OS
Molecular Weight	328.472
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4386346

Promethazine hydroxyethyl quaternary derivative of promethazine with antihistamine and anticholinergic properties. The drug lacked the sedative properties of promethazine. It was used in the clinic under tradename Aprobit.

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:44:08 GMT 2023` Edited by `admin` on `Sat Dec 16 10:44:08 GMT 2023`
Record UNII	O3842T8RNK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROMETHAZINE HYDROXYETHYL CHLORIDE

Common Name

English

Promethazine hydroxyethyl chloride [WHO-DD]

Common Name

English

10H-PHENOTHIAZINE-10-ETHANAMINIUM, N-(2-HYDROXYETHYL)-N,N,.ALPHA.-TRIMETHYL-, CHLORIDE

Systematic Name

English

(2-HYDROXYETHYL)DIMETHYL(1-METHYL-2-PHENOTHIAZIN-10-YLETHYL)AMMONIUM CHLORIDE

Systematic Name

English

N-HYDROXYETHYLPROMETHAZINE CHLORIDE [MI]

Common Name

English

APROBIT

Brand Name

English

10H-PHENOTHIAZINE-10-ETHANAMINIUM, N-(2-HYDROXYETHYL)-N,N,.ALPHA.-TRIMETHYL-, CHLORIDE (1:1)

Systematic Name

English

AMMONIUM, (2-HYDROXYETHYL)DIMETHYL(1-METHYL-2-PHENOTHIAZIN-10-YLETHYL)-, CHLORIDE

Systematic Name

English

Code System Code Type Description

SMS_ID

100000085088