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Details

Stereochemistry ACHIRAL
Molecular Formula C16H13Cl2NO4
Molecular Weight 354.185
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of QUINFAMIDE

SMILES

ClC(Cl)C(=O)N1CCCC2=CC(OC(=O)C3=CC=CO3)=CC=C12

InChI

InChIKey=SBJGFIXQRZOVTO-UHFFFAOYSA-N
InChI=1S/C16H13Cl2NO4/c17-14(18)15(20)19-7-1-3-10-9-11(5-6-12(10)19)23-16(21)13-4-2-8-22-13/h2,4-6,8-9,14H,1,3,7H2

HIDE SMILES / InChI

Molecular Formula C16H13Cl2NO4
Molecular Weight 354.185
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Quinafimide is an investigational compound that has been used in trials for the treatment of Amoebiasis and Helminthiasis. This phase 4 trial combined Quinfamide with the approved compound Mebendazole. The details of the mechanism of action are not known, but the overall effect is intraluminal immobilization of the Entamoeba.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Unknown
Secondary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
In phase 4 clinical trial for the treatment of intestinal helminthiasis and amebiasis, Quinfamide (200 mg) was given orally in combination with oral Mebendazole (600 mg).
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
O1ZB1046R1
Record Status Validated (UNII)
Record Version