Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C40H38F5N3O3S |
| Molecular Weight | 735.805 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COCCN1CCC(CC1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C(=O)CN4C(SCC5=C(F)C(F)=CC=C5)=CC(=O)C6=C4C=CC=C6
InChI
InChIKey=NNBGCSGCRSCFEA-UHFFFAOYSA-N
InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3
| Molecular Formula | C40H38F5N3O3S |
| Molecular Weight | 735.805 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Rilapladib (SB659032) is a potent and selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Inhibition of Lp-PLA2 can reduce peripheral measures of inflammation. Rilapladib has been evaluated for treatment in Alzheimer’s disease and atherosclerosis. Initial results from clinical trials in Alzheimer patients suggests that oral administration of rilapladib may slow down the progression of Alzheimer’s disease. Initial evidence has also been found that inhibition of Lp-PLA2 may attenuate intimal macrophage accumulation and consequently stabilize atherosclerotic plaque.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:31:10 GMT 2023
by
admin
on
Fri Dec 15 16:31:10 GMT 2023
|
| Record UNII |
O14CWE893Z
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C29703
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C76401
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
8704
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
O14CWE893Z
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
9918381
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
SUB64595
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
CHEMBL2104981
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
DB05119
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
412950-08-4
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
100000134795
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
DTXSID50194281
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY | |||
|
RR-58
Created by
admin on Fri Dec 15 16:31:10 GMT 2023 , Edited by admin on Fri Dec 15 16:31:10 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
