Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C40H48N2O6.2I |
Molecular Weight | 906.6279 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[I-].[I-].COC1=CC=C2C[C@@H]3C4=C(OC5=CC=C(C[C@H]6C7=C(CC[N+]6(C)C)C=C(OC)C(OC1=C2)=C7)C=C5)C(OC)=C(OC)C=C4CC[N+]3(C)C
InChI
InChIKey=DIGFQJFCDPKEPF-OIUSMDOTSA-L
InChI=1S/C40H48N2O6.2HI/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1
Molecular Formula | C40H48N2O6 |
Molecular Weight | 652.8189 |
Charge | 2 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | HI |
Molecular Weight | 127.9124 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Metocurine, also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant through the neuromuscular blockade. It antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. Patients chronically receiving anticonvulsants are relatively resistant to metocurine.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: neuromuscular Sources: https://www.ncbi.nlm.nih.gov/pubmed/7023284 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | METOCURINE IODIDE Approved UseMetocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market. |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.46 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7023284/ |
0.3 mg/kg single, intravenous dose: 0.3 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
METOCURINE serum | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
1.05 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7023284/ |
0.3 mg/kg single, intravenous dose: 0.3 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
METOCURINE serum | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7023284/ |
0.3 mg/kg single, intravenous dose: 0.3 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
METOCURINE serum | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
11.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7023284/ |
0.3 mg/kg single, intravenous dose: 0.3 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
METOCURINE serum | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
PubMed
Title | Date | PubMed |
---|---|---|
Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapy. | 1999 Jan |
|
Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain. | 2003 Aug 22 |
|
Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. | 2008 Aug |
|
Reduced blood pressure lability during emergence from anaesthesia in rats: a pilot study using clonidine. | 2008 Feb |
|
Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. | 2009 Jan |
|
Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide. | 2010 |
|
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:05:16 GMT 2023
by
admin
on
Fri Dec 15 15:05:16 GMT 2023
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Record UNII |
O0U0E87X7F
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29696
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C66131
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m7490
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CHEMBL1259
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24244
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100000087514
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7601-55-0
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O0U0E87X7F
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C032943
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SUB33048
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203206
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DTXSID9022944
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231-510-3
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DB00416
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36388
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SUB01752MIG
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Related Record | Type | Details | ||
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ACTIVE MOIETY |