PROSTALENE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H36O5
Molecular Weight	380.5182
Optical Activity	( + / - )
Defined Stereocenters	5 / 5
E/Z Centers	3
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC[C@@](C)(O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=C=CCCC(=O)OC

InChI

InChIKey=GNIYHUSSKSFYBD-MFZPGRHISA-N

InChI=1S/C22H36O5/c1-4-5-10-14-22(2,26)15-13-18-17(19(23)16-20(18)24)11-8-6-7-9-12-21(25)27-3/h7-8,13,15,17-20,23-24,26H,4-5,9-12,14,16H2,1-3H3/b15-13+/t6?,17-,18-,19+,20-,22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H36O5
Molecular Weight	380.5182
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	3
Optical Activity	UNSPECIFIED

Description
Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.2012 | https://www.drugs.com/international/prostalene.html

Prostalene is an analogue of prostaglandin PGF-2 alpha. It is used for the control of estrus in mares.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
prostaglandin F receptor (FP) 1 Target ID: 1.00009712E8 Gene Symbol: PTGFR Sources: https://www.ncbi.nlm.nih.gov/pubmed/550139 \| https://www.ncbi.nlm.nih.gov/pubmed/289794	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pregnancy 65 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16726434 https://www.ncbi.nlm.nih.gov/pubmed/289794 https://www.ncbi.nlm.nih.gov/pubmed/1049488	Preventing		Approved 8429	Synchrocept B Approved Use Indications for use: For the control of estrus in mares.

PubMed

Title	Date	PubMed
Summary of the effect of prostalene, a new synthetic prostaglandin, on the breeding efficiency of mares.	1976 Nov	1049488
Sources of variation in response intervals after prostaglandin treatment in mares with functional corpora lutea.	1979	289794

Patents

Sample Use Guides

In Vivo Use Guide

Conditions of use in horses --(1) Amount. Administer 5 micrograms per kilogram of body weight as a single subcutaneous injection.

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:17:25 GMT 2023` Edited by `admin` on `Fri Dec 15 16:17:25 GMT 2023`
Record UNII	O02SWY8981
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROSTALENE

Official Name

English

PROSTALENE [MART.]

Common Name

English

SYNCHROCEPT

Brand Name

English

PROSTALENE [USAN]

Common Name

English

(±)-METHYL 7-((1R*,2R*,3R*,5S*)-3,5-DIHYDROXY-2-((E)-3-HYDROXY-3-METHYL-1-OCTENYL)CYCLOPENTYL)-4,5-HEPTADIENOATE

Systematic Name

English

prostalene [INN]

Common Name

English

RS-9390

Code

English

PROSTA-4,5,13-TRIEN-1-OIC ACID, 9,11,15-TRIHYDROXY-15-METHYL-, METHYL ESTER, (9.ALPHA.,11.ALPHA.,13E,15R)-, (±)-

Common Name

English

PROSTALENE [GREEN BOOK]

Common Name

English

PROSTALENE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

CFR

21 CFR 522.2012

Created by admin on Fri Dec 15 16:17:25 GMT 2023 , Edited by admin on Fri Dec 15 16:17:25 GMT 2023

Code System Code Type Description

ChEMBL

CHEMBL2105317

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

NCI_THESAURUS

C76903

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

CAS

54120-61-5

Created by admin on Fri Dec 15 16:17:25 GMT 2023 , Edited by admin on Fri Dec 15 16:17:25 GMT 2023

PRIMARY

FDA UNII

O02SWY8981

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

MERCK INDEX

m9261

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

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Merck Index

DRUG BANK

DB11454

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

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EPA CompTox

DTXSID50102160

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

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EVMPD

SUB10133MIG

Created by admin on Fri Dec 15 16:17:25 GMT 2023 , Edited by admin on Fri Dec 15 16:17:25 GMT 2023

PRIMARY

ECHA (EC/EINECS)

258-984-4

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

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INN

3873

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

PUBCHEM

6436031

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

SMS_ID

100000080832

Created by admin on Fri Dec 15 16:17:26 GMT 2023 , Edited by admin on Fri Dec 15 16:17:26 GMT 2023

PRIMARY

Related Record Type Details


					O02SWY8981

PROSTALENE

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.2012 | https://www.drugs.com/international/prostalene.html

Originator

Approval Year

Targets

Conditions

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.2012 | https://www.drugs.com/international/prostalene.html