PENTETATE ZINC TRISODIUM

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H18N3O10.3Na.Zn
Molecular Weight	522.685
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[Na+].[Zn++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O

InChI

InChIKey=HVASDHJNLYRZEA-UHFFFAOYSA-I

InChI=1S/C14H23N3O10.3Na.Zn/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;;;;/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);;;;/q;3*+1;+2/p-5

HIDE SMILES / InChI

Molecular Formula	Zn
Molecular Weight	65.409
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H18N3O10
Molecular Weight	388.3068
Charge	-5
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/021749lbl.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/18830865 | https://www.truthinaging.com/ingredients/pentasodium-pentetate
Curator's Comment: description was created based on several sources, including: https://www.federalregister.gov/articles/2011/08/19/2011-21227/determination-that-pentetate-calcium-trisodium-trisodium-calcium-diethylenetriaminepentaacetate

on as chelating agents in cosmetics. Pentasodium Pentetate is readily soluble in water, but the corresponding free acid is not. Pentasodium Pentetate is used in almost 400 cosmetic products over a wide range of product categories, although it is mostly used in hair dyes and colors at use concentrations of 0.1% to 1.0%. Pentetic Acid and Pentasodium Pentetate inactivate metallic ions, such as calcium and magnesium, to maintain stability and appearance of cosmetic products. The inactivation of other metallic ions such as iron or copper also helps to prevent the oxidative deterioration of cosmetics and personal care products.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Metallic ions 7 Target ID: Metallic ions Sources: https://www.ncbi.nlm.nih.gov/pubmed/18830865	Chelating Agent 139
Radioactive metals 7 Target ID: CHEMBL2366037 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/021749lbl.pdf	Chelating Agent 139

Conditions

Condition	Modality	Highest Phase	Product
Acne 100 Sources: https://www.drugs.com/otc/110273/dermaklear-akne-treatment-with-sulfur.html	Inactive ingredient	Approved 8583	DermaKlear Akne Treatment with Sulfur Approved Use Uses for the treatment of acne. Dries acne blemishes and allows skin to heal. Helps prevent new acne blemishes from forming. Launch Date 1940
Contamination with plutonium, americium, or curium 7 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/021749lbl.pdf	Diagnostic	Withdrawn	PENTETATE CALCIUM TRISODIUM Approved Use Ca-DTPA is indicated for treatment of individuals with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination. Launch Date 2004
Internal contamination with plutonium, americium, or curium 7 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021751s008lbl.pdf	Palliative	Approved 8583	PENTETATE ZINC TRISODIUM Approved Use Pentetate zinc trisodium injection is a radiomitigation chelator indicated for treatment of individuals with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination. Launch Date 2004

C_max

Value	Dose	Co-administered	Analyte	Population
1.6 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16257469/	29.4 μmol/kg single, intravenous dose: 29.4 μmol/kg route of administration: Intravenous experiment type: SINGLE co-administered:		PENTETIC ACID plasma	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
0.007 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16257469/	29.4 μmol/kg single, intravenous dose: 29.4 μmol/kg route of administration: Intravenous experiment type: SINGLE co-administered:		PENTETIC ACID plasma	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
0.53 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16257469/	29.4 μmol/kg single, intravenous dose: 29.4 μmol/kg route of administration: Intravenous experiment type: SINGLE co-administered:		PENTETIC ACID plasma	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
0.5 g 1 times / day multiple, subcutaneous Dose: 0.5 g, 1 times / day Route: subcutaneous Route: multiple Dose: 0.5 g, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2923478	unhealthy, 5-20 years) Health Status: unhealthy Age Group: 5-20 years) Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/2923478	Sources: https://pubmed.ncbi.nlm.nih.gov/2923478
4 g 1 times / day multiple, intramuscular Overdose Dose: 4 g, 1 times / day Route: intramuscular Route: multiple Dose: 4 g, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021749s008lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021749s008lbl.pdf	Other AEs: Hemochromatosis... Other AEs: Hemochromatosis (grade 5, 3 patients) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021749s008lbl.pdf

AEs

AE	Significance	Dose	Population
Hemochromatosis	grade 5, 3 patients	4 g 1 times / day multiple, intramuscular Overdose Dose: 4 g, 1 times / day Route: intramuscular Route: multiple Dose: 4 g, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021749s008lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021749s008lbl.pdf

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:35739	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35739
ChemicalBook	CB5303977	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5303977
eMolecules	497513	https://www.emolecules.com/cgi-bin/more?vid=497513
MolPort	MolPort-002-324-582	https://www.molport.com/shop/molecule-link/MolPort-002-324-582
ZINC	ZINC000019419017	http://zinc15.docking.org/substances/ZINC000019419017

PubMed

Title	Date	PubMed
Chelation of zinc amplifies induction of growth hormone mRNA levels in cultured rat pituitary tumor cells.	2000 Feb	10720163
Towards the characterisation of heavy metals in dredged canal sediments and an appreciation of 'availability': two examples from the UK.	2001	11428147
Comparison of written reports of mammography, sonography and magnetic resonance mammography for preoperative evaluation of breast lesions, with special emphasis on magnetic resonance mammography.	2001	11250746
Blood-pool scintigraphic diagnosis of fractured lumbar vertebral hemangioma.	2001 Apr	11392297
Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates.	2001 Apr	11332030
Biodistribution properties of (111)indium-labeled C-functionalized trans-cyclohexyl diethylenetriaminepentaacetic acid humanized 3S193 diabody and F(ab')(2) constructs in a breast carcinoma xenograft model.	2001 Apr	11309358
In vitro evaluation of intravascular stent artifacts in three-dimensional MR angiography.	2001 Apr	11283419
A cream containing the chelator DTPA (diethylenetriaminepenta-acetic acid) can prevent contact allergic reactions to metals.	2001 Apr	11260238
Magnetic resonance pharmacoangiography to detect and predict chemotherapy delivery to solid tumors.	2001 Apr 1	11306485
The effect of the nasal cycle on mucociliary clearance.	2001 Feb	11298159
Different chelators and different peptides together influence the in vitro and mouse in vivo properties of 99Tcm.	2001 Feb	11258408
Clearance of Tc-99m DTPA aerosol in mismatched and matched pulmonary perfusion defects.	2001 Feb	11201465
Inhibitors of advanced glycation end product-associated protein cross-linking.	2001 Feb 14	11341999
Metal chelators inhibit S-nitrosation of Cys beta 93 in oxyhemoglobin.	2001 Feb 28	11456789
Seizures in multiple sclerosis.	2001 Jan	11207788
Single-cell cytotoxicity with radiolabeled antibodies.	2001 Jan	11205908
Biokinetics of 111In-DTPA-D-Phe(1)-octreotide in nude mice transplanted with a human carcinoid tumor.	2001 Jan	11182566
Contrast-enhanced MR imaging of experimental acute tubular necrosis.	2001 Jan	11167336
Somatostatin receptor imaging, therapy and new strategies in patients with neuroendocrine tumours.	2001 Jan	11136306
Surveillance of peripheral arterial bypass grafts with three-dimensional MR angiography: comparison with digital subtraction angiography.	2001 Jan	11133569
Diffusion of paramagnetically labeled proteins in cartilage: enhancement of the 1-D NMR imaging technique.	2001 Jan	11133285
Buttock granulomas: a consequence of intramuscular injection of Sandostatin detected by In-111 octreoscan.	2001 Jul	11416760
Detection of cerebrospinal fluid leak by dual-isotope spect with In-111 DTPA and Tc-99m HMDP.	2001 Jul	11416747
Effects of peroxynitrite on the reactivity of diabetic rat aorta.	2001 Jul	11408833
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).	2001 Jul 1	11431325
The effect of irradiation on the biodistribution of radiolabeled pegylated liposomes.	2001 Jul 1	11395251
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.	2001 Jul-Aug	11459464
Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains.	2001 Jul-Aug	11459459
A synthetic macromolecule for sentinel node detection: (99m)Tc-DTPA-mannosyl-dextran.	2001 Jun	11390562
Multi-level disruption of the spinal nerve root sleeves in spontaneous spinal cerebrospinal fluid leakage--two case reports.	2001 Mar	11372561
Clinical relevance of lower Hib response in DTPa-based combination vaccines.	2001 Mar 21	11257348
Magnetic resonance imaging of a benign Brenner tumor with an ipsilateral simple cyst.	2001 May	11409485
Significance of (111)In-DTPA chelate in renal radioactivity levels of (111)In-DTPA-conjugated peptides.	2001 May	11395320
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.	2001 May	11395314
Cardiovascular effects caused by rapid administration of gadoversetamide injection in anesthetized dogs.	2001 May	11394361
Relationships between chromium biomagnification ratio, accumulation factor, and mycorrhizae in plants growing on tannery effluent-polluted soil.	2001 May	11392761
Contrast agents in acute myocardial infarction.	2001 May	11390263
Dysprosium-bearing red cells as potential transverse relaxation agents for MRI.	2001 May	11323820
Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells.	2001 May 1	11311127
Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines.	2001 May 14	11348721
Antitumor and antiangiogenic effects of somatostatin receptor-targeted in situ radiation with (111)In-DTPA-JIC 2DL.	2001 May 15	11341788

Patents

Sample Use Guides

In Vivo Use Guide

Adults and Adolescents: A single 1.0 gram initial dose of Ca-DTPA administered intravenously Pediatrics (less than 12 years of age): A single initial dose of 14 mg/kg administered intravenously not exceed 1.0 gram.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:04:56 GMT 2025` Edited by `admin` on `Mon Mar 31 18:04:56 GMT 2025`
Record UNII	NXU65IC8PG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZINC TRISODIUM PENTETATE

Preferred Name

English

PENTETATE ZINC TRISODIUM

Common Name

English

TRISODIUM (N,N-BIS(2-(BIS(CARBOXYLATOMETHYL)AMINO)ETHYL)GLYCINATO(5-))ZINCATE(3-)

Common Name

English

PENTETATE ZINC TRISODIUM [VANDF]

Common Name

English

TRISODIUM ZINC DTPA

Common Name

English

PENTETATE ZINC TRISODIUM [HSDB]

Common Name

English

DIETHYLENETRIAMINE PENTACETIC ACID TRISODIUM ZINC SALT

Common Name

English

PENTETATE ZINC TRISODIUM [ORANGE BOOK]

Common Name

English

DIETHYLENETRIAMINEPENTAACETIC ACID, ZINC TRISODIUM SALT

Common Name

English

TRISODIUM ZINC DIETHYLENETRIAMINEPENTAACETATE

Common Name

English

ZINCATE(3-), (N,N-BIS(2-(BIS(CARBOXYMETHYL)AMINO)ETHYL)GLYCINATO(5-))-, TRISODIUM

Common Name

English

Pentetate zinc trisodium [WHO-DD]

Common Name

English

ZINC TRISODIUM PENTETATE [MART.]

Common Name

English

PENTETATE ZINC TRISODIUM [JAN]

Common Name

English

KELAZIN

Brand Name

English

ZINC-DTPA

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C62357