ZOLAMINE

US Previously Marketed

First approved in 1951

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H21N3OS
Molecular Weight	291.412
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(CN(CCN(C)C)C2=NC=CS2)C=C1

InChI

InChIKey=KYBJXENQEZJILU-UHFFFAOYSA-N

InChI=1S/C15H21N3OS/c1-17(2)9-10-18(15-16-8-11-20-15)12-13-4-6-14(19-3)7-5-13/h4-8,11H,9-10,12H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C15H21N3OS
Molecular Weight	291.412
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/zolamine.html | https://books.google.ru/books?id=Dg8HCAAAQBAJ&pg=PA53&lpg=PA53&dq=ZOLAMINE retrieved from Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques By JUCKER, p. 53 | https://www.genome.jp/dbget-bin/www_bget?dr:D06376

Zolamine is an antihistamine with local anesthetic properties. Zolamine is reported to have a low incidence of side effects and is used clinically both as an antihistaminic and a topical local anesthetic.

Approval Year

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L23QG
Compound Cloud	14386
Compound Cloud	14387
HongKong Chemhere	SCE20783
MuseChem	M049385
ZINC	ZINC000000002257	http://zinc15.docking.org/substances/ZINC000000002257

PubMed

Title	Date	PubMed
Laparoscopic diagnosis and treatment of aortic vascular prosthetic graft infections in a porcine model.	2008 Jan	17719807

Patents

Sample Use Guides

In Vivo Use Guide

Eight female pigs were anaesthetized byinitially intramuscular injection of a 1 ml mixture con-sisting of zolamine 5 mg/ml, butorphanol 1 mg/ml,ketamine 10 mg/ml and xylazin 2 mg/ml, followedby continuous intravenous infusion of propofol10 mg/kg per hour and fentanyl 0.025 mg/kg perhour throughout the operation.

Route of Administration: Intramuscular

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:06 GMT 2023` Edited by `admin` on `Fri Dec 15 15:13:06 GMT 2023`
Record UNII	NXB79TB0N2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZOLAMINE

Official Name

English

2-((2-(DIMETHYLAMINO)ETHYL)-(P-METHOXYBENZYL)AMINO)THIAZOLE

Common Name

English

zolamine [INN]

Common Name

English

ZOLAMINE [MI]

Common Name

English

1,2-ETHANEDIAMINE, N-((4-METHOXYPHENYL)METHYL)-N',N'-DIMETHYL-N-2-THIAZOLYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578