U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 19:23:44 UTC 2023
Edited
by admin
on Thu Jul 06 19:23:44 UTC 2023
Protein Type MONOCLONAL ANTIBODY FUSION PROTEIN
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
NW9K8C1JN3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BINTRAFUSP ALFA
USAN   INN  
Official Name English
M-7824
Preferred Name English
MSB-0011359C
Code English
MSB0011359C
Code English
IMMUNOTHERAPIC BIFUNCTIONAL FUSION PROTEIN COMPRISED OF A FULLY HUMAN IGG1 MONOCLONAL ANTIBODY (AVELUMAB) AGAINST HUMAN PROGRAMMED DEATH-LIGAND 1 (PD-L1) FUSED TO THE SOLUBLE EXTRACELLULAR DOMAIN OF TRANSFORMING GROWTH FACTOR-.BETA. (TGF-.BETA.) RECEPTOR
Common Name English
Bintrafusp alfa [WHO-DD]
Common Name English
IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED CELL DEATH 1 LIGAND PROTEIN)(HUMAN .GAMMA.1-CHAIN) FUSION PROTEIN WITH 2-137-TRANSFORMING GROWTH FACTOR .BETA. RECEPTOR (HUMAN GENE TGFBR2 ISOFORM 1), DISULFIDE WITH ANTI-(HUMAN PROGRAMMED CELL DEATH 1 LIGAND PRO
Common Name English
BINTRAFUSP ALFA [JAN]
Common Name English
BINTRAFUSP ALFA [USAN]
Common Name English
8L9YQ2N6PA
Code English
ANTI-PD-L1/TGFBETARII FUSION PROTEIN MSB0011359C
Common Name English
bintrafusp alfa [INN]
Common Name English
M7824
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 663818
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
Code System Code Type Description
DRUG BANK
DB15387
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
USAN
HI-200
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
INN
10665
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
CAS
1918149-01-5
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
CAS
2252197-15-0
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
SUPERSEDED
NCI_THESAURUS
C124229
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
FDA UNII
NW9K8C1JN3
Created by admin on Thu Jul 06 19:23:44 UTC 2023 , Edited by admin on Thu Jul 06 19:23:44 UTC 2023
PRIMARY
From To
2_586 2_591
2_569 2_584
1_586 1_591
1_569 1_584
2_525 2_549
1_525 1_549
2_509 2_515
1_509 1_515
2_502 2_519
1_502 1_519
2_499 2_532
1_499 1_532
1_22 1_96
1_147 1_203
1_223 3_215
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
2_22 2_96
2_147 2_203
2_223 4_215
2_264 2_324
2_370 2_428
3_22 3_90
3_138 3_197
4_22 4_90
4_138 4_197
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 1_518
N 1_542
N 1_602
N 2_300
N 2_518
N 2_542
N 2_602
Related Record Type Details
TARGET -> INHIBITOR
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL