NITROCLOFENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H8Cl2N2O6
Molecular Weight	359.118
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(Cl)C=C(C=C1CC2=C(O)C(=CC(Cl)=C2)[N+]([O-])=O)[N+]([O-])=O

InChI

InChIKey=DIRNVHCNISKNQF-UHFFFAOYSA-N

InChI=1S/C13H8Cl2N2O6/c14-8-2-6(13(19)11(4-8)17(22)23)1-7-3-9(16(20)21)5-10(15)12(7)18/h2-5,18-19H,1H2

HIDE SMILES / InChI

Molecular Formula	C13H8Cl2N2O6
Molecular Weight	359.118
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2614861 | https://books.google.ru/books?id=xUlaDwAAQBAJ&pg=PT226&lpg=PT226&dq=NITROCLOFENE+drug&source=bl&ots=CnAWiThBdR&sig=ACfU3U0hYnDScpi8QKsoMZyOn1uUtAk4Sw&hl=en&sa=X&ved=2ahUKEwif4vvVuf_iAhURxIsKHcfqA4I4ChDoATACegQIBhAB#v=onepage&q=NITROCLOFENE%20drug&f=false retrieved from Drugs: Synonyms and Properties: Synonyms and Properties edited by George W.A Milne

Nitroclofene is an anthelminthic drug. Nitroclofene is a selective inhibitor of the fumarate reductase system of the adult liver fluke at a concentration of 4 umol/L. The enzyme plays an important role in the process of energy utilization. Consequently, it possesses good flukicidal activity against both Fasciola hepatica and F. gigantica.

Approval Year

PubMed

Title	Date	PubMed
Some pharmacokinetic data of the liver-fluke anthelmintic nitroclofene in ruminant and pre-ruminant kids.	1989 Dec	2614861

Patents

Sample Use Guides

In Vivo Use Guide

The pharmacokinetic results suggest that extensive biodegradation of nitroclofene in the forestomach system may account for the reduced oral bioavailability of the drug in ruminants. At an oral dose rate of 10 mg/kg nitroclofene was not effective 16 weeks post-experimental infection (dose: 450 metacercariae), whereas after i.m. injection of 3 mg/kg a 95-100% reduction in EPG (eggs per g faeces) has been recorded in similar infected goats.

Route of Administration: Other

In Vitro Use Guide

Nitroclofene is a selective inhibitor of the fumarate reductase system of the adult liver fluke at a concentration of 4 umol/L.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:13:18 GMT 2023` Edited by `admin` on `Sat Dec 16 17:13:18 GMT 2023`
Record UNII	NT0758136A
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NITROCLOFENE

Official Name

English

4,6'-DICHLORO-4',6-DINITRO-2,2'-METHYLENEDIPHENOL

Systematic Name

English

nitroclofene [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250