Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H22ClN3O |
| Molecular Weight | 355.861 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC1=C(O)C=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1
InChI
InChIKey=ZVMMVSSEAMUNGI-UHFFFAOYSA-N
InChI=1S/C20H22ClN3O/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18/h4-11,23,25H,12H2,1-3H3,(H,22,24)
| Molecular Formula | C20H22ClN3O |
| Molecular Weight | 355.861 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. | 2009 Apr 9 |
|
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | 2009 Mar 12 |
|
| Synthesis, β-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent. | 2018 Mar 25 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:29:09 UTC 2023
by
admin
on
Sat Dec 16 11:29:09 UTC 2023
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| Record UNII |
NSC8QP4B6Z
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
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459133-38-1
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10316203
Created by
admin on Sat Dec 16 11:29:09 UTC 2023 , Edited by admin on Sat Dec 16 11:29:09 UTC 2023
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ACTIVE MOIETY |
Title : Single-blind, placebo-controlled, randomized study testing single ascending doses of
GSK369796 in healthy subjects
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