Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H22ClN3O |
Molecular Weight | 355.861 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC1=C(O)C=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1
InChI
InChIKey=ZVMMVSSEAMUNGI-UHFFFAOYSA-N
InChI=1S/C20H22ClN3O/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18/h4-11,23,25H,12H2,1-3H3,(H,22,24)
Molecular Formula | C20H22ClN3O |
Molecular Weight | 355.861 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL613897 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19222165 |
PubMed
Title | Date | PubMed |
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Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. | 2009 Apr 9 |
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Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | 2009 Mar 12 |
|
Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus. | 2017 Jan |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:29:09 GMT 2023
by
admin
on
Sat Dec 16 11:29:09 GMT 2023
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Record UNII |
NSC8QP4B6Z
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Record Status |
Validated (UNII)
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
Title : Single-blind, placebo-controlled, randomized study testing single ascending doses of
GSK369796 in healthy subjects
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