GSK-369796

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H22ClN3O
Molecular Weight	355.861
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC1=C(O)C=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1

InChI

InChIKey=ZVMMVSSEAMUNGI-UHFFFAOYSA-N

InChI=1S/C20H22ClN3O/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18/h4-11,23,25H,12H2,1-3H3,(H,22,24)

HIDE SMILES / InChI

Molecular Formula	C20H22ClN3O
Molecular Weight	355.861
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ferriprotoporphyrin IX 43 Target ID: CHEMBL613897 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19222165	Binding Agent 1064

PubMed

Title	Date	PubMed
Synthesis, β-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent.	2018 Mar 25	29126722

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:29:09 GMT 2023` Edited by `admin` on `Sat Dec 16 11:29:09 GMT 2023`
Record UNII	NSC8QP4B6Z
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GSK-369796

Common Name

English

NTBISQ

Common Name

English

N-TERT-BUTYL ISOQUINE

Common Name

English

N-TERT-BUTYLISOQUINE

Common Name

English

PHENOL, 5-((7-CHLORO-4-QUINOLINYL)AMINO)-2-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-

Systematic Name

English

2-((TERT-BUTYLAMINO)METHYL)-5-((7-CHLORO-4-QUINOLYL)AMINO)PHENOL

Systematic Name

English

GSK369796

Common Name

English

BDBM50134936

Code

English

ZINC1912685

Code

English

GSK 369796

Code

English

Code System Code Type Description

FDA UNII

NSC8QP4B6Z

Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023

PRIMARY

CAS

459133-38-1

Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023

PRIMARY

PUBCHEM

10316203

Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023

PRIMARY

Related Record Type Details


					536WV61NML

Plasmodium falciparum

TARGET ORGANISM->INHIBITOR

Amount:

Related Record Type Details


					NSC8QP4B6Z

GSK-369796

ACTIVE MOIETY

Comments:

Title : Single-blind, placebo-controlled, randomized study testing single ascending doses of GSK369796 in healthy subjects