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Details

Stereochemistry ACHIRAL
Molecular Formula C20H22ClN3O
Molecular Weight 355.861
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-369796

SMILES

CC(C)(C)NCC1=C(O)C=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1

InChI

InChIKey=ZVMMVSSEAMUNGI-UHFFFAOYSA-N
InChI=1S/C20H22ClN3O/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18/h4-11,23,25H,12H2,1-3H3,(H,22,24)

HIDE SMILES / InChI

Molecular Formula C20H22ClN3O
Molecular Weight 355.861
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
2009 Apr 9
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
2009 Mar 12
Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus.
2017 Jan
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:29:09 GMT 2023
Edited
by admin
on Sat Dec 16 11:29:09 GMT 2023
Record UNII
NSC8QP4B6Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GSK-369796
Common Name English
NTBISQ
Common Name English
N-TERT-BUTYL ISOQUINE
Common Name English
N-TERT-BUTYLISOQUINE
Common Name English
PHENOL, 5-((7-CHLORO-4-QUINOLINYL)AMINO)-2-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-
Systematic Name English
2-((TERT-BUTYLAMINO)METHYL)-5-((7-CHLORO-4-QUINOLYL)AMINO)PHENOL
Systematic Name English
GSK369796
Common Name English
BDBM50134936
Code English
ZINC1912685
Code English
GSK 369796
Code English
Code System Code Type Description
FDA UNII
NSC8QP4B6Z
Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023
PRIMARY
CAS
459133-38-1
Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023
PRIMARY
PUBCHEM
10316203
Created by admin on Sat Dec 16 11:29:09 GMT 2023 , Edited by admin on Sat Dec 16 11:29:09 GMT 2023
PRIMARY
Related Record Type Details
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Title : Single-blind, placebo-controlled, randomized study testing single ascending doses of GSK369796 in healthy subjects