Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H22ClN3O |
| Molecular Weight | 355.861 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC1=CC=C(NC2=C3C=CC(Cl)=CC3=NC=C2)C=C1O
InChI
InChIKey=ZVMMVSSEAMUNGI-UHFFFAOYSA-N
InChI=1S/C20H22ClN3O/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18/h4-11,23,25H,12H2,1-3H3,(H,22,24)
| Molecular Formula | C20H22ClN3O |
| Molecular Weight | 355.861 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis, β-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent. | 2018-03-25 |
|
| Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus. | 2017-01 |
|
| Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. | 2009-04-09 |
|
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | 2009-03-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:27:43 GMT 2025
by
admin
on
Tue Apr 01 16:27:43 GMT 2025
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| Record UNII |
NSC8QP4B6Z
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| Record Status |
Validated (UNII)
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Created by
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ACTIVE MOIETY |
Title : Single-blind, placebo-controlled, randomized study testing single ascending doses of
GSK369796 in healthy subjects
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