Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.228 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C(=O)NC1=O
InChI
InChIKey=DWRXFEITVBNRMK-JAGXHNFQSA-N
InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7+,9-/m1/s1
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.228 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. | 1979 Jan |
|
| Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice. | 1979 Nov |
|
| Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil. | 1980 Jun |
|
| 7-Aminoquinolines. A novel class of agents active against herpesviruses. | 1988 Jul |
|
| Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. | 1995 Apr |
|
| Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds. | 1995 Jul |
|
| Anti-herpesvirus activity profile of 4'-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-beta-D-2'-fluoro-4'-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus. | 1998 Aug |
|
| Efficacy of select antivirals against Cryptosporidium parvum in vitro. | 1998 Nov 1 |
|
| Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir. | 1999 Oct |
|
| Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol. | 2001 Nov 23 |
|
| Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents. | 2003 Feb |
|
| Lipid-mediated protein delivery of suicide nucleoside kinases. | 2003 Oct 15 |
|
| Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides. | 2004 |
|
| Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. | 2004 Mar 19 |
|
| Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster. | 2005 Aug |
|
| Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides. | 2005 Dec 15 |
|
| The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture. | 2006 |
|
| 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods. | 2006 Feb 15 |
|
| Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides. | 2008 Jul 18 |
|
| Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA. | 2009 Sep 10 |
|
| Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. | 2010 Oct |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:33:14 GMT 2023
by
admin
on
Sat Dec 16 08:33:14 GMT 2023
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| Record UNII |
NS9U4BEG7Y
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| Record Status |
Validated (UNII)
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| Record Version |
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68929
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NS9U4BEG7Y
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65049
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605-23-2
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210-083-7
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DTXSID201194189
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