Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H14N2O6 |
Molecular Weight | 258.228 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C(=O)NC1=O
InChI
InChIKey=DWRXFEITVBNRMK-JAGXHNFQSA-N
InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7+,9-/m1/s1
Molecular Formula | C10H14N2O6 |
Molecular Weight | 258.228 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil. | 1979 Aug |
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(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. | 1979 Jun |
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Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice. | 1979 Nov |
|
Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases. | 1981 Sep |
|
Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs. | 1986 Mar |
|
7-Aminoquinolines. A novel class of agents active against herpesviruses. | 1988 Jul |
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Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides. | 1989 Feb |
|
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. | 1995 Apr |
|
Anti-herpesvirus activity profile of 4'-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-beta-D-2'-fluoro-4'-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus. | 1998 Aug |
|
Efficacy of select antivirals against Cryptosporidium parvum in vitro. | 1998 Nov 1 |
|
Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir. | 1999 Oct |
|
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase. | 2001 Feb |
|
2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase. | 2001 Mar 15 |
|
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. | 2001 May 21 |
|
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol. | 2001 Nov 23 |
|
Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents. | 2003 Feb |
|
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. | 2004 Mar 19 |
|
Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells. | 2005 Apr 2 |
|
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides. | 2005 Dec 15 |
|
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods. | 2006 Feb 15 |
|
Substrate specificity of feline and canine herpesvirus thymidine kinase. | 2008 Aug |
|
Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides. | 2008 Jul 18 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:33:14 GMT 2023
by
admin
on
Sat Dec 16 08:33:14 GMT 2023
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Record UNII |
NS9U4BEG7Y
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Record Status |
Validated (UNII)
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Record Version |
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68929
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NS9U4BEG7Y
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65049
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605-23-2
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210-083-7
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DTXSID201194189
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