NORDEFRIN HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H13NO3.ClH
Molecular Weight	219.665
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.C[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1

InChI

InChIKey=YRJLEOWRVNBAOI-WFZUHFMFSA-N

InChI=1S/C9H13NO3.ClH/c1-5(10)9(13)6-2-3-7(11)8(12)4-6;/h2-5,9,11-13H,10H2,1H3;1H/t5-,9-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H13NO3
Molecular Weight	183.2044
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20831932 | https://www.ncbi.nlm.nih.gov/pubmed/13525505

Nordefrin is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor. Nordefrin is a racemic mixture of levo- and dextro- isomers and levonordefrin to be 100 to 200 times more active than dextro-nordefrin in raising blood pressure. Nordefrin is a structural isomer of epinephrine and levonordefrin produced a greater increase in heart rate than epinephrine.

Approval Year

PubMed

Title	Date	PubMed
High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in Parkinsonian patients.	1983 Oct 14	6643597
Baroreceptor function in man following peripheral alpha 1- and alpha 2-adrenoceptor stimulation.	1987	2891531

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:29:08 GMT 2023` Edited by `admin` on `Fri Dec 15 15:29:08 GMT 2023`
Record UNII	NGO8K841ZV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORDEFRIN HYDROCHLORIDE

Common Name

English

(±)-GA-(1-AMINOETHYL)-3,4-DIHYDROXYBENZYL ALCOHOL HYDROCHLORIDE

Common Name

English

(±)-.ALPHA.-METHYLNORADRENALINE HYDROCHLORIDE

Common Name

English

(±)-COBEFRIN HYDROCHLORIDE

Common Name

English

1,2-BENZENEDIOL, 4-((1R,2S)-2-AMINO-1-HYDROXYPROPYL)-, HYDROCHLORIDE, REL-

Common Name

English

NORDEFRIN HCL

Common Name

English

BENZYL ALCOHOL, .ALPHA.-(1-AMINOETHYL)-3,4-DIHYDROXY-, HYDROCHLORIDE, ERYTHRO-(±)-

Common Name

English

NORDEFRIN HYDROCHLORIDE [MI]

Common Name

English

DL-CORBADRINE HYDROCHLORIDE

Common Name

English

1,2-BENZENEDIOL, 4-((1R,2S)-2-AMINO-1-HYDROXYPROPYL)-, HYDROCHLORIDE (1:1), REL-

Common Name

English

Nordefrin hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C87053