NORAMIDOPYRINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H15N3O
Molecular Weight	217.267
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC1=C(C)N(C)N(C1=O)C2=CC=CC=C2

InChI

InChIKey=JILCEWWZTBBOFS-UHFFFAOYSA-N

InChI=1S/C12H15N3O/c1-9-11(13-2)12(16)15(14(9)3)10-7-5-4-6-8-10/h4-8,13H,1-3H3

HIDE SMILES / InChI

Molecular Formula	C12H15N3O
Molecular Weight	217.267
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.	2001 Nov	11792017
Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone.	2001 Nov	11668360
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.	2001 Sep	11699610
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.	2002 Dec	12445177
Bioavailability of two metamizole (dipyrone) solutions as single doses of 2 g versus metamizole capsules.	2002 Jul	12139210
Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.	2002 May	11972485
Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac.	2003 Jan 15	12504796
Simultaneous determination of residues of dipyrone and its major metabolites in milk, bovine muscle, and porcine muscle by liquid chromatography/mass spectrometry.	2005 Mar-Apr	15859077
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.	2007 Aug	17435173
Solid-phase extraction followed by liquid chromatography-time-of-flight-mass spectrometry to evaluate pharmaceuticals in effluents. A pilot monitoring study.	2007 Jul	17607393
Inhibition of cyclooxygenases by dipyrone.	2007 Jun	17435797
[Analysis of three metabolite residues of dipyrone in bovine muscle and pork muscle using high performance liquid chromatography].	2007 Nov	18257301
[Favorable outcome of acute porphyric neuropathy after treatment with heme arginate].	2007 Nov	18033050
Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.	2008	19040780
Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.	2008 May	18294672
Treatment of postherpetic neuralgia: focus on pregabalin.	2009	19503762
Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma.	2009 May	21083168
Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).	2010 Aug	20619430
Population pharmacokinetic analysis of the active product of dipyrone.	2010 Dec	21084034
Scavenging activity of aminoantipyrines against hydroxyl radical.	2010 Jun	20172632

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:46:27 GMT 2023` Edited by `admin` on `Fri Dec 15 17:46:27 GMT 2023`
Record UNII	NER31DE951
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORAMIDOPYRINE

Common Name

English

1,5-DIMETHYL-4-METHYLAMINO-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE

Systematic Name

English

Noramidopyrine [WHO-DD]

Common Name

English

N-METHYL-4-AMINOPHENAZONE

Systematic Name

English

N-METHYLAMINOPHENAZONE

Systematic Name

English

NORAMINOPYRINE

Common Name

English

4-Methylaminoantipyrine

Common Name

English

METAMIZOLE SODIUM MONOHYDRATE IMPURITY C [EP IMPURITY]

Common Name

English

Code System Code Type Description

CAS

519-98-2