Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C34H50F2N4O3 |
Molecular Weight | 600.7826 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)N1C(=O)N(CC2CCOCC2)C[C@@]13C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(=O)C5CCC(F)(F)CC5)C6=CC=CC=C6
InChI
InChIKey=YZGXEGUSPLSQOJ-MJOCGKAJSA-N
InChI=1S/C34H50F2N4O3/c1-24(2)40-32(42)38(22-25-13-18-43-19-14-25)23-33(40)20-28-8-9-29(21-33)39(28)17-12-30(26-6-4-3-5-7-26)37-31(41)27-10-15-34(35,36)16-11-27/h3-7,24-25,27-30H,8-23H2,1-2H3,(H,37,41)/t28-,29+,30-,33-/m0/s1
Molecular Formula | C34H50F2N4O3 |
Molecular Weight | 600.7826 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:36:05 GMT 2023
by
admin
on
Sat Dec 16 11:36:05 GMT 2023
|
Record UNII |
NDX9EX5ATP
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Code | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
NDX9EX5ATP
Created by
admin on Sat Dec 16 11:36:05 GMT 2023 , Edited by admin on Sat Dec 16 11:36:05 GMT 2023
|
PRIMARY | |||
|
891824-47-8
Created by
admin on Sat Dec 16 11:36:05 GMT 2023 , Edited by admin on Sat Dec 16 11:36:05 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
VCH-286 is being developed as a novel drug for the treatment of human immunodeficiency virus (HIV). VCH-286
(IC90 HIV-1Ba-L ~0.21 nM) targets the chemokine coreceptor CCR5 on the cell surface and specifically blocks the entry of CCR5-tropic strains of HIV-1 into host cells.
|
||
|
ACTIVE MOIETY |
IC50s obtained for VCH-286 against the R5 viruses: HIV-1BAL = 0.23 nM and HIV-1CC1/85 = 0.34 nM.
|
||
|
ACTIVE MOIETY |
Class: Antiretroviral, Small molecule; Mechanism of Action: CCR5 receptor antagonist; Highest Development Phase: Phase I for HIV infections; Most Recent Events: 12 Mar 2009 ViroChem Pharma has been acquired and merged into Vertex Pharmaceuticals, 12 Mar 2009 ViroChem Pharma has been acquired by Vertex Pharmaceuticals, 12 Feb 2009 Pharmacokinetics, adverse events and antimicrobial activity data from a phase I trial in HIV infections added
|