FLUMEZAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19FN4S
Molecular Weight	330.423
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=CC(F)=CC=C3NC4=C2C=C(C)S4

InChI

InChIKey=JBHUBOISLBWHAR-UHFFFAOYSA-N

InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H19FN4S
Molecular Weight	330.423
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2879325 | https://www.nature.com/articles/nrd1758

FLUMEZAPINE, a benzodiazepine derivative, is an antipsychotic agent. It is a potent blocker of dopamine D2 and of some serotonin receptors. Its clinical development was dropped due to toxicology concerns.

Originator

Approval Year

PubMed

Title	Date	PubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.	1984 Dec	6527743
Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats.	1985 Oct	2867152
Flumezapine, an antagonist of central dopamine and serotonin receptors.	1986 Oct	2879325

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:23:33 UTC 2023` Edited by `admin` on `Fri Dec 15 15:23:33 UTC 2023`
Record UNII	NA9GM10X6C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUMEZAPINE

Official Name

English

LY-120363

Code

English

LY120363

Code

English

flumezapine [INN]

Common Name

English

7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Systematic Name

English

FLUMEZAPINE [USAN]

Common Name

English

10H-THIENO(2,3-B)(1,5)BENZODIAZEPINE, 7-FLUORO-2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-

Systematic Name

English

Code System Code Type Description

CAS

61325-80-2